Abstract

Background:This study estimates the risk of stroke within 5 years of newly diagnosed dementia among elderly persons aged 65 and above. We examined the relationship between antipsychotic usage and development of stroke in patients with dementia.Methods:We conducted a nationwide 5-year population-based study using data retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The study cohort comprised 2243 patients with dementia aged ≥65 years who had at least one inpatient service claim or at least 2 ambulatory care claims, whereas the comparison cohort consisted of 6714 randomly selected subjects (3 for every dementia patient) and were matched with the study group according to sex, age, and index year. We further classified dementia patients into 2 groups based on their history of antipsychotic usage. A total of 1450 patients were classified into the antipsychotic usage group and the remaining 793 patients were classified into the non-antipsychotic usage group. Cox proportional-hazards regressions were performed to compute the 5-year stroke-free survival rates after adjusting for potentially confounding factors.Results:The dementia patients have a 2-fold greater risk of developing stroke within 5 years of diagnosis compared to non-dementia age- and sex-matched subjects, after adjusting for other risk factors (95% confidence interval (CI) = 2.58-3.08; P

Original languageEnglish
Article numbere61771
JournalPLoS One
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 23 2013

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dementia
Taiwan
stroke
Antipsychotic Agents
Dementia
Stroke
Health insurance
Population
Hazards
health insurance
risk estimate
Health Insurance
Ambulatory Care
gender
cohort studies
Inpatients
Cohort Studies
Survival Rate
confidence interval
Databases

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Population-Based 5-Year Follow-Up Study in Taiwan of Dementia and Risk of Stroke. / Liu, Mu En; Tsai, Shih Jen; Chang, Wei Chiao; Hsu, Chun Hung; Lu, Ti; Hung, Kuo Sheng; Chiu, Wen Ta; Chang, Wei Pin.

In: PLoS One, Vol. 8, No. 4, e61771, 23.04.2013.

Research output: Contribution to journalArticle

Liu, Mu En ; Tsai, Shih Jen ; Chang, Wei Chiao ; Hsu, Chun Hung ; Lu, Ti ; Hung, Kuo Sheng ; Chiu, Wen Ta ; Chang, Wei Pin. / Population-Based 5-Year Follow-Up Study in Taiwan of Dementia and Risk of Stroke. In: PLoS One. 2013 ; Vol. 8, No. 4.
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