Polyunsaturated fatty acids levels and initial presentation of somatic symptoms induced by interferon-alpha therapy in patients with chronic hepatitis C viral infection

Jane Pei Chen Chang, Hsueh Chou Lai, Hui Ting Yang, Wen Pang Su, Cheng Yuan Peng, Piotr Gałecki, Anna Walczewska, Carmine M. Pariante, Kuan Pin Su

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Somatic symptoms are common in depressive disorder and are similar to sickness behaviors due to inflammatory activation after cytokine administration. Omega-3 polyunsaturated fatty acids (PUFAs) are natural anti-inflammatory agents and may reduce inflammation-induced behavioral changes. The aim of this study was to investigate the role of PUFAs on the development of somatic symptoms and depression in patients of hepatitis C virus infection (HCV) receiving interferon-alpha therapy (IFN-α) in a prospective manner. Methods: In this 24-week, prospective cohort study, 43 patients with chronic HCV ongoing IFN-α therapy were assessed with the mini-international neuropsychiatric interview for major depressive episodes and neurotoxicity rating scale (NRS) for somatic symptoms. Results: One-third later developed IFN-α-induced depression (depression (DEP) group). As compared to subjects without depression, DEP group had higher NRS scores (P < 0.001), lower eicosapentaenoic acid (EPA) levels (P = 0.038) at week 2. Somatic symptoms, regardless of painful/non-painful characteristics, had positive association with arachidonic acid (P < 0.05), and negative association with EPA (P < 0.05). Conclusion: This study implies that early intervention with omega-3 PUFAs might be a promising strategy to prevent depression and somatic symptoms in patients receiving cytokine therapy.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalNutritional Neuroscience
Volume20
Issue number5
DOIs
Publication statusPublished - May 28 2017
Externally publishedYes

Fingerprint

Chronic Hepatitis C
Virus Diseases
Unsaturated Fatty Acids
Interferon-alpha
Depression
Eicosapentaenoic Acid
Omega-3 Fatty Acids
Hepacivirus
Therapeutics
Cytokines
Illness Behavior
Depressive Disorder
Arachidonic Acid
Medically Unexplained Symptoms
Cohort Studies
Anti-Inflammatory Agents
Prospective Studies
Interviews
Inflammation

Keywords

  • Depression
  • n-3
  • Omega-3
  • Painful symptoms
  • PUFAs

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Polyunsaturated fatty acids levels and initial presentation of somatic symptoms induced by interferon-alpha therapy in patients with chronic hepatitis C viral infection. / Chang, Jane Pei Chen; Lai, Hsueh Chou; Yang, Hui Ting; Su, Wen Pang; Peng, Cheng Yuan; Gałecki, Piotr; Walczewska, Anna; Pariante, Carmine M.; Su, Kuan Pin.

In: Nutritional Neuroscience, Vol. 20, No. 5, 28.05.2017, p. 291-296.

Research output: Contribution to journalArticle

Chang, Jane Pei Chen ; Lai, Hsueh Chou ; Yang, Hui Ting ; Su, Wen Pang ; Peng, Cheng Yuan ; Gałecki, Piotr ; Walczewska, Anna ; Pariante, Carmine M. ; Su, Kuan Pin. / Polyunsaturated fatty acids levels and initial presentation of somatic symptoms induced by interferon-alpha therapy in patients with chronic hepatitis C viral infection. In: Nutritional Neuroscience. 2017 ; Vol. 20, No. 5. pp. 291-296.
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