Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni

Yu Jen Chen, Po Ching Cheng, Ching Nan Lin, Hui Fen Liao, Yu Yawn Chen, Chin Chu Chen, Kin Mu Lee

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evaluating cytokine expression; on immunomodulation, by evaluating spleen cells; and on Schistosoma mansoni infection in mice. The induction of high levels of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) mRNA was detected in BALB/c mice after 2, 4, and 6 weeks of oral AC-PS administration. After 6 weeks of oral AC-PS administration to the BALB/c mice, the number of splenic dendritic cells, macrophages, and the surface expression of CD8α+ and major histocompatibility class II I-A/I-E on dendritic cells increased. The CD4+/CD8+ ratio and number of B cells among splenocytes were also augmented. By using a disease model of parasitic infection, we found that AC-PS treatment inhibited S. mansoni infection in BALB/c mice. AC-PS appears to modulate the immune system of mice and has potential for preventing S. mansoni infection.

Original languageEnglish
Pages (from-to)458-467
Number of pages10
JournalInternational Immunopharmacology
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 2008
Externally publishedYes

Keywords

  • Antrodia camphorata
  • Dendritic cells
  • Immunomodulation
  • Polysaccharide
  • Schistosoma mansoni

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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