Polyploidy in malignant melanoma

J. Whang‐Peng, P. Chretien, T. Knutsen

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Chromosome studies were performed on primary or metastatic malignant melanoma from 6 patients. All of them were aneuploid and had either hyperdiploid, near triploid, tetraploid, or hypertetraploid cell lines. Two of them had definite stem‐cell lines, but the other 4 cases had a wide distribution of chromosome numbers with no apparent cell lines. Three of the 6 patients had one or more marker chromosomes, i.e., large submetacentrics or long acrocentrics. These results lead us to speculate that the rapid cell growth is due not only to selection but also to continuous replication defects and mitotic abnormalities.

Original languageEnglish
Pages (from-to)1216-1223
Number of pages8
JournalCancer
Volume25
Issue number5
DOIs
Publication statusPublished - Jan 1 1970
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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