Polyphenolics-rich Psithum guajava budding leaf extract can reverse diabetes-induced functional impairment of cavernosal smooth muscle relaxation in rats

Chia Hung Liu, Chiung Chi Peng, Chiung Huei Peng, Chiu Lan Hsieh, Kuan Chou Chen, Robert Y. Peng

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Diabetes Mellitus (DM) related Advanced Glycation End products (AGEs) are considered to induce functional impairment of cavernosal smooth muscle relaxation and cause Erectile Dysfunction (ED). We used rats to examine the in vitro effects of Psidium guajava L. (Myrtaceae) budding leaf extract (PE) on pharmacological relaxation of corpus cavernosum smooth muscle strips obtained from diabetic rats. After 8 weeks, the mean glycosylated haemoglobin (HbA1c), serum cholesterol and triglyceride concentrations were significantly higher in the non-PB diabetic than in the age-matched control animals. Interestingly, in diabetic animals fed PE, serum cholesterol and triglyceride levels were significantly lower than in their peers given a standard diet. The administration of PE to diabetic animals for 8 weeks reversed the expected impaired relaxation response and nitric oxide production in cavernosal smooth muscle exposed to acetylcholine or electrical field stimulation. The administration of PE to rats with 8 weeks of uncontrolled diabetes reverses DM-induced harmful effects on vascular smooth muscle.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalResearch Journal of Medical Sciences
Volume4
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Muscle Relaxation
Smooth Muscle
Diabetes Mellitus
Triglycerides
Myrtaceae
Cholesterol
Psidium
Advanced Glycosylation End Products
Glycosylated Hemoglobin A
Erectile Dysfunction
Serum
Vascular Smooth Muscle
Electric Stimulation
Acetylcholine
Nitric Oxide
Pharmacology
Diet

Keywords

  • Corpus cavernosum
  • Diabetes mellitus
  • Erectile dysfunction
  • Psidium guajava

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Polyphenolics-rich Psithum guajava budding leaf extract can reverse diabetes-induced functional impairment of cavernosal smooth muscle relaxation in rats. / Liu, Chia Hung; Peng, Chiung Chi; Peng, Chiung Huei; Hsieh, Chiu Lan; Chen, Kuan Chou; Peng, Robert Y.

In: Research Journal of Medical Sciences, Vol. 4, No. 1, 2010, p. 25-32.

Research output: Contribution to journalArticle

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