Polymyositis complicating donor lymphocyte infusion after stem cell transplantation for relapsed chronic myeloid leukemia

Report of a case and review of literature

Feng Cheng Liu, Chen Hung Chen, Tsu Yi Chao

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polymyositis may occur along with other manifestations of chronic graft vs host disease after allogeneic bone marrow transplantation (BMT). Donor lymphocyte infusion (DLI) could produce durable remissions in relapsed patients with chronic myelogenous leukemia (CML) but it may contribute to the development of polymyositis. We report in this study a 25-year-old man who suffered from a relapse of CML 4 years after a sibling human leukocyte antigen-matched allogenic BMT. The patient developed polymyositis 18 months after DLI. Mini-pulse therapy with methylprednisolone was effective for his proximal weakness and elevated creatine phosphokinase. There was no relapse of symptoms of polymyositis on tapering of the medication.

Original languageEnglish
Pages (from-to)1207-1210
Number of pages4
JournalClinical Rheumatology
Volume26
Issue number7
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Fingerprint

Polymyositis
Stem Cell Transplantation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tissue Donors
Lymphocytes
Homologous Transplantation
Bone Marrow Transplantation
Recurrence
Methylprednisolone
Graft vs Host Disease
Creatine Kinase
HLA Antigens
Siblings
Therapeutics

Keywords

  • Donor lymphocyte infusion
  • Graftvs host disease
  • Polymyositis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

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abstract = "Polymyositis may occur along with other manifestations of chronic graft vs host disease after allogeneic bone marrow transplantation (BMT). Donor lymphocyte infusion (DLI) could produce durable remissions in relapsed patients with chronic myelogenous leukemia (CML) but it may contribute to the development of polymyositis. We report in this study a 25-year-old man who suffered from a relapse of CML 4 years after a sibling human leukocyte antigen-matched allogenic BMT. The patient developed polymyositis 18 months after DLI. Mini-pulse therapy with methylprednisolone was effective for his proximal weakness and elevated creatine phosphokinase. There was no relapse of symptoms of polymyositis on tapering of the medication.",
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