Abstract

Background: Polymyalgia rheumatica (PMR) is a relatively common rheumatic disease, particularly in the elderly. Vasculitis is associated with PMR and theoretically makes such patients susceptible to vascular events such as stroke. This study aims to explore the frequency and risk of stroke among patients with PMR through a population-based case-controlled study. Methods: The study included 781 patients with PMR from the Taiwan Longitudinal Health Insurance Database between 2001 and 2005. We randomly extracted 3,905 other patients, matched with the study group in terms of sex and age, as a control population. Each subject was individually tracked for a three-year period to identify those who had strokes. Stratified Cox proportional hazard regression was employed to evaluate the risk of stroke, after adjusting for socio-demographic characteristics and comorbidities. Results: We found that 386 out of 4,686 sampled patients (8.24%) had stroke during the three-year follow-up period, including 113 patients with PMR (14.47% of the PMR group) and 273 controls (6.98% of the control group). The stratified Cox proportional hazard regression showed that the adjusted hazard ratio of stroke for patients with PMR was 2.09 times that of controls (95% CI = 1.63-2.66, p

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalCerebrovascular Diseases
Volume32
Issue number5
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Polymyalgia Rheumatica
Stroke
Control Groups
Health Insurance
Vasculitis
Rheumatic Diseases
Taiwan
Population
Blood Vessels
Comorbidity
Demography
Databases

Keywords

  • Polymyalgia rheumatica
  • Stroke
  • Vasculitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Polymyalgia rheumatica and the risk of stroke: A three-year follow-up study",
abstract = "Background: Polymyalgia rheumatica (PMR) is a relatively common rheumatic disease, particularly in the elderly. Vasculitis is associated with PMR and theoretically makes such patients susceptible to vascular events such as stroke. This study aims to explore the frequency and risk of stroke among patients with PMR through a population-based case-controlled study. Methods: The study included 781 patients with PMR from the Taiwan Longitudinal Health Insurance Database between 2001 and 2005. We randomly extracted 3,905 other patients, matched with the study group in terms of sex and age, as a control population. Each subject was individually tracked for a three-year period to identify those who had strokes. Stratified Cox proportional hazard regression was employed to evaluate the risk of stroke, after adjusting for socio-demographic characteristics and comorbidities. Results: We found that 386 out of 4,686 sampled patients (8.24{\%}) had stroke during the three-year follow-up period, including 113 patients with PMR (14.47{\%} of the PMR group) and 273 controls (6.98{\%} of the control group). The stratified Cox proportional hazard regression showed that the adjusted hazard ratio of stroke for patients with PMR was 2.09 times that of controls (95{\%} CI = 1.63-2.66, p",
keywords = "Polymyalgia rheumatica, Stroke, Vasculitis",
author = "Kang, {Jiunn Horng} and Sheu, {Jau Jiuan} and Lin, {Herng Ching}",
year = "2011",
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volume = "32",
pages = "497--503",
journal = "Cerebrovascular Diseases",
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AU - Kang, Jiunn Horng

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AB - Background: Polymyalgia rheumatica (PMR) is a relatively common rheumatic disease, particularly in the elderly. Vasculitis is associated with PMR and theoretically makes such patients susceptible to vascular events such as stroke. This study aims to explore the frequency and risk of stroke among patients with PMR through a population-based case-controlled study. Methods: The study included 781 patients with PMR from the Taiwan Longitudinal Health Insurance Database between 2001 and 2005. We randomly extracted 3,905 other patients, matched with the study group in terms of sex and age, as a control population. Each subject was individually tracked for a three-year period to identify those who had strokes. Stratified Cox proportional hazard regression was employed to evaluate the risk of stroke, after adjusting for socio-demographic characteristics and comorbidities. Results: We found that 386 out of 4,686 sampled patients (8.24%) had stroke during the three-year follow-up period, including 113 patients with PMR (14.47% of the PMR group) and 273 controls (6.98% of the control group). The stratified Cox proportional hazard regression showed that the adjusted hazard ratio of stroke for patients with PMR was 2.09 times that of controls (95% CI = 1.63-2.66, p

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