Polymorphisms of the Parkin gene in sporadic Parkinson's disease among Chinese in Taiwan

Chaur Jong Hu, Shing Ming Sung, Hsing Cheng Liu, Cheng Chun Lee, Chang H. Tsai, Jan Gowth Chang

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Abstract

The role of genetics in Parkinson's disease (PD), previously controversial, is now documented by several studies. A major breakthrough has been the discovery of two single-gene defects in familial PD. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the α- synuclein gene has been identified in cases of autosomal dominant familial PD. Mutations in the Parkin gene can induce autosomal recessive juvenile parkinsonism. A polymorphism of R/W366 in the Parkin gene was found to be associated with a protective factor for sporadic PD. We surveyed the polymorphisms of the Parkin gene, including S/N167, R/W366 and V/L380, in 92 cases of sporadic PD and 98 nonaffected individuals in Taiwanese Chinese. The allele frequencies of these polymorphisms are not significantly different between PD and nonaffected controls. We conclude that polymorphisms of the Parkin gene, S/N167, R/W366, V/L380, are not genetic factors for sporadic PD among Chinese in Taiwan. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalEuropean Neurology
Volume44
Issue number2
Publication statusPublished - Aug 2000
Externally publishedYes

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Keywords

  • Chinese
  • Parkin gene
  • Parkinson's disease
  • Polymorphism
  • Taiwan

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Hu, C. J., Sung, S. M., Liu, H. C., Lee, C. C., Tsai, C. H., & Chang, J. G. (2000). Polymorphisms of the Parkin gene in sporadic Parkinson's disease among Chinese in Taiwan. European Neurology, 44(2), 90-93.