Polymorphisms of human nonmetastatic clone 23 type 1 gene and neoplastic lesions of uterine cervix

Chi Yen Feng, Po Hui Wang, Hsiu Ting Tsai, Yi Torng Tee, Jiunn Liang Ko, Shiuan Chih Chen, Ching Yi Lin, Chih Ping Han, Jia Sin Yang, Yu Fan Liu, Long Yau Lin, Shun Fa Yang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Hypothesis: Single-nucleotide polymorphisms (SNP) in promoter of human nonmetastatic clone 23 type 1 (nm23-H1) may affect their binding with transcription factors and affect promoter activity as well as gene transcription. Therefore, we investigated the impact of the nm23-H1 gene polymorphisms on the neoplastic lesions of uterine cervix in mid-Taiwan women (women who live in the central area of Taiwan). We expected that women with different genotypes in nm23-H1 polymorphisms, such as rs34214448, rs16949649, or rs2302254, may have different incidences of cervical neoplasia. Materials and Methods: In total, 366 blood samples were collected from 244 healthy women and 122 patients with cervical neoplasia to analyze 3 nm23-H1 gene single-nucleotide polymorphisms (rs34214448, rs16949649, and rs2302254). Results: The heterozygous genotypes, TG in rs34214448 or TC in rs16949649, were differentially distributed between patients with cervical neoplasia and normal women (Hommel adjusted P =.0440 and.0435, respectively) as compared to their homozygotes. Moreover, compared to those with wild-type homozygotes and heterozygotes, women with variant homozygotes TT in rs34214448 or CC in rs16949649 exert different distributions between patients with cervical neoplasia and normal women (P =.058 and.058). Interestingly, we found the genotype distribution of rs34214448 has significant association with that of rs16949649 with high consistency. Conclusions: Mid-Taiwan women with the polymorphic heterozygotes TG in rs34214448 or TC in rs16949649 of human nonmetastatic clone 23 type 1 promoter have the tendency to develop cervical neoplasia while compared to their homozygous counterparts. However, women with variant homozygotes TT in rs34214448 or CC in rs16949649 exhibit less tendency as compared to those with wild-type homozygotes and heterozygotes.

Original languageEnglish
Pages (from-to)886-893
Number of pages8
JournalReproductive Sciences
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Keywords

  • heterozygote
  • homozygote
  • human nonmetastatic clone 23 type 1 gene
  • neoplasia of uterine cervix
  • single-nucleotide polymorphisms

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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