Polyketides from the littoral plant associated fungus Pseudallescheria boydii

Ya Chih Chang, Tzu Shing Deng, Ka Lai Pang, Che Jen Hsiao, Yi Ying Chen, Shye Jye Tang, Zong-Huei Li

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Four previously unreported chemical entities, boydone A (1), boydone B (2), botryorhodine F (3), and botryorhodine G (4), along with five known compounds, fusidilactone A (5), (R)-(-)-mevalonolactone (6), (R)-(-)-lactic acid (7), ovalicin (8), and botryorhodine C (9), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Pseudallescheria boydii NTOU2362. The structures of 1-9 were characterized on the basis of their spectroscopic data analyses. The absolute configurations of 1 and 2 were established by comparison with the literature and the modified Mosher's method. The growth inhibitory activities of 1-9 against the A549 non-small-cell lung cancer cell line were evaluated, and 2 and 8 exhibited moderate to potent bioactivities with GI50 values of 41.3 and 4.1 μM, respectively, in comparison with fluorouracil (GI50 = 3.6 μM).

Original languageEnglish
Pages (from-to)1796-1800
Number of pages5
JournalJournal of Natural Products
Volume76
Issue number9
DOIs
Publication statusPublished - Sep 27 2013

Fingerprint

Pseudallescheria
Polyketides
Fungi
Non-Small Cell Lung Carcinoma
Fluorouracil
Lactic Acid
Cells
Cell Line
Growth
Bioactivity
botryorhodine G
boydone B
mevalonolactone
botryorhodine F
fusidilactone A
boydone A
ethyl acetate
ovalicin

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Chang, Y. C., Deng, T. S., Pang, K. L., Hsiao, C. J., Chen, Y. Y., Tang, S. J., & Li, Z-H. (2013). Polyketides from the littoral plant associated fungus Pseudallescheria boydii. Journal of Natural Products, 76(9), 1796-1800. https://doi.org/10.1021/np400192q

Polyketides from the littoral plant associated fungus Pseudallescheria boydii. / Chang, Ya Chih; Deng, Tzu Shing; Pang, Ka Lai; Hsiao, Che Jen; Chen, Yi Ying; Tang, Shye Jye; Li, Zong-Huei.

In: Journal of Natural Products, Vol. 76, No. 9, 27.09.2013, p. 1796-1800.

Research output: Contribution to journalArticle

Chang, YC, Deng, TS, Pang, KL, Hsiao, CJ, Chen, YY, Tang, SJ & Li, Z-H 2013, 'Polyketides from the littoral plant associated fungus Pseudallescheria boydii', Journal of Natural Products, vol. 76, no. 9, pp. 1796-1800. https://doi.org/10.1021/np400192q
Chang YC, Deng TS, Pang KL, Hsiao CJ, Chen YY, Tang SJ et al. Polyketides from the littoral plant associated fungus Pseudallescheria boydii. Journal of Natural Products. 2013 Sep 27;76(9):1796-1800. https://doi.org/10.1021/np400192q
Chang, Ya Chih ; Deng, Tzu Shing ; Pang, Ka Lai ; Hsiao, Che Jen ; Chen, Yi Ying ; Tang, Shye Jye ; Li, Zong-Huei. / Polyketides from the littoral plant associated fungus Pseudallescheria boydii. In: Journal of Natural Products. 2013 ; Vol. 76, No. 9. pp. 1796-1800.
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