Polyketides from the littoral plant associated fungus Pseudallescheria boydii

Ya Chih Chang, Tzu Shing Deng, Ka Lai Pang, Che Jen Hsiao, Yi Ying Chen, Shye Jye Tang, Zong-Huei Li

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11 Citations (Scopus)

Abstract

Four previously unreported chemical entities, boydone A (1), boydone B (2), botryorhodine F (3), and botryorhodine G (4), along with five known compounds, fusidilactone A (5), (R)-(-)-mevalonolactone (6), (R)-(-)-lactic acid (7), ovalicin (8), and botryorhodine C (9), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Pseudallescheria boydii NTOU2362. The structures of 1-9 were characterized on the basis of their spectroscopic data analyses. The absolute configurations of 1 and 2 were established by comparison with the literature and the modified Mosher's method. The growth inhibitory activities of 1-9 against the A549 non-small-cell lung cancer cell line were evaluated, and 2 and 8 exhibited moderate to potent bioactivities with GI50 values of 41.3 and 4.1 μM, respectively, in comparison with fluorouracil (GI50 = 3.6 μM).

Original languageEnglish
Pages (from-to)1796-1800
Number of pages5
JournalJournal of Natural Products
Volume76
Issue number9
DOIs
Publication statusPublished - Sep 27 2013

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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