Polygenic panels predicting the susceptibility of multiple upper aerodigestive tract cancer in oral cancer patients

Huei Tzu Chien, Chi Chin Yeh, Chi Kuang Young, Tzu Ping Chen, Chun Ta Liao, Hung Ming Wang, Kai Lun Cho, Shiang Fu Huang

Research output: Contribution to journalArticlepeer-review

Abstract

Head and neck cancer was closely related with habitual use of cigarette and alcohol. Those cancer patients are susceptible to develop multiple primary tumors (MPTs). In this study, we utilized the single nucleotide polymorphisms (SNPs) array (Affymetrix Axion Genome-Wide TWB 2.0 Array Plate) to investigate patients’ risks of developing multiple primary cancers. We recruited 712 male head and neck cancer patients between Mar 1996 and Feb 2017. Two hundred and eighty-six patients (40.2%) had MPTs and 426 (59.8%) had single cancer. Four hundred and twelve normal controls were also recruited. A list of seventeen factors was extracted and ten factors were demonstrated to increase the risks of multiple primary cancers (alcohol drinking, rs118169127, rs149089400, rs76367287, rs61401220, rs141057871, rs7129229, older age, rs3760265, rs9554264; all were p value < 0.05). Polygenic scoring model was built and the area under curve to predict the risk developing MPTs is 0.906. Alcohol drinking, among the seventeen factors, was the most important risk factor to develop MPT in upper aerodigestive tract (OR: 7.071, 95% C.I.: 2.134–23.434). For those with high score in polygenic model, routine screening of upper digestive tract including laryngoscope and esophagoscope is suggested to detect new primaries early.

Original languageEnglish
Article number425
JournalJournal of Personalized Medicine
Volume11
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • Head and neck cancer
  • Multiple primary cancer
  • Single nucleotide polymorphism
  • SNP array
  • Upper aerodigestive tract

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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