Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice

Shu Lin Chang, Cicero L. Chang, Yi Ming Chiang, Rong-Hong Hsieh, Chii-Ruey Tzeng, Tung Kung Wu, Huey Kang Sytwu, Lie Fen Shyur, Wen Chin Yang

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Compelling evidence suggests that infiltrating CD4 + type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain levels of blood sugar and insulin in NOD mice in a dose-dependent manner and elevated the serum IgE levels regulated by Th2 cytokines in NOD mice. Moreover, the butanol fraction inhibited the differentiation of naïve helper T (Th0) cells into Th1 cells but enhanced their transition into type 11 helper T (Th2) cells using an in vitro T cell differentiation assay. Two polyacetylenic compounds, 2-β-D- glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne, identified from the butanol fraction also prevented the onset of diabetes like the butanol fraction. The latter compound showed a stronger activity for T cell differentiation than the former. In summary, the butanol fraction of B. pilosa and its polyacetylenes can prevent diabetes plausibly via suppressing the differentiation of Th0 cells into Th1 cells and promoting that of Th0 cells into Th2 cells.

Original languageEnglish
Pages (from-to)1045-1051
Number of pages7
JournalPlanta Medica
Volume70
Issue number11
DOIs
Publication statusPublished - Nov 2004

Fingerprint

Bidens
Bidens pilosa
Butanols
Inbred NOD Mouse
T-cells
insulin-dependent diabetes mellitus
butanol
Medical problems
Helper-Inducer T-Lymphocytes
Type 1 Diabetes Mellitus
T-lymphocytes
Th1 Cells
diabetes
cell differentiation
mice
Cell Differentiation
Th2 Cells
Polyacetylenes
cells
polyacetylenes

Keywords

  • Asteraceae
  • Autoimmune diseases
  • Bidens pilosa
  • Differentiation
  • Non-obese diabetes
  • T helper cells

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice. / Chang, Shu Lin; Chang, Cicero L.; Chiang, Yi Ming; Hsieh, Rong-Hong; Tzeng, Chii-Ruey; Wu, Tung Kung; Sytwu, Huey Kang; Shyur, Lie Fen; Yang, Wen Chin.

In: Planta Medica, Vol. 70, No. 11, 11.2004, p. 1045-1051.

Research output: Contribution to journalArticle

Chang, Shu Lin ; Chang, Cicero L. ; Chiang, Yi Ming ; Hsieh, Rong-Hong ; Tzeng, Chii-Ruey ; Wu, Tung Kung ; Sytwu, Huey Kang ; Shyur, Lie Fen ; Yang, Wen Chin. / Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice. In: Planta Medica. 2004 ; Vol. 70, No. 11. pp. 1045-1051.
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AU - Chang, Shu Lin

AU - Chang, Cicero L.

AU - Chiang, Yi Ming

AU - Hsieh, Rong-Hong

AU - Tzeng, Chii-Ruey

AU - Wu, Tung Kung

AU - Sytwu, Huey Kang

AU - Shyur, Lie Fen

AU - Yang, Wen Chin

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N2 - Compelling evidence suggests that infiltrating CD4 + type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain levels of blood sugar and insulin in NOD mice in a dose-dependent manner and elevated the serum IgE levels regulated by Th2 cytokines in NOD mice. Moreover, the butanol fraction inhibited the differentiation of naïve helper T (Th0) cells into Th1 cells but enhanced their transition into type 11 helper T (Th2) cells using an in vitro T cell differentiation assay. Two polyacetylenic compounds, 2-β-D- glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne, identified from the butanol fraction also prevented the onset of diabetes like the butanol fraction. The latter compound showed a stronger activity for T cell differentiation than the former. In summary, the butanol fraction of B. pilosa and its polyacetylenes can prevent diabetes plausibly via suppressing the differentiation of Th0 cells into Th1 cells and promoting that of Th0 cells into Th2 cells.

AB - Compelling evidence suggests that infiltrating CD4 + type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain levels of blood sugar and insulin in NOD mice in a dose-dependent manner and elevated the serum IgE levels regulated by Th2 cytokines in NOD mice. Moreover, the butanol fraction inhibited the differentiation of naïve helper T (Th0) cells into Th1 cells but enhanced their transition into type 11 helper T (Th2) cells using an in vitro T cell differentiation assay. Two polyacetylenic compounds, 2-β-D- glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne, identified from the butanol fraction also prevented the onset of diabetes like the butanol fraction. The latter compound showed a stronger activity for T cell differentiation than the former. In summary, the butanol fraction of B. pilosa and its polyacetylenes can prevent diabetes plausibly via suppressing the differentiation of Th0 cells into Th1 cells and promoting that of Th0 cells into Th2 cells.

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