Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies

Tai Li Tsou, Shang Tao Tang, Yu Chuan Huang, Jing Ran Wu, Jenn Jong Young, Hsian-Jenn Wang

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0 ≤ F ≤ 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Volume16
Issue number2
DOIs
Publication statusPublished - Feb 1 2005
Externally publishedYes

Fingerprint

Bandages
Ciprofloxacin
Ethylene glycol
Wounds and Injuries
Membranes
Pharmaceutical Preparations
Benzoin
Ultraviolet radiation
Ether
Agar
Ethers
Pharmacokinetics
Monomers
Drug Liberation
ethylene dimethacrylate
hydroxyethyl methacrylate
Radiation
Kinetics
Water

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies. / Tsou, Tai Li; Tang, Shang Tao; Huang, Yu Chuan; Wu, Jing Ran; Young, Jenn Jong; Wang, Hsian-Jenn.

In: Journal of Materials Science: Materials in Medicine, Vol. 16, No. 2, 01.02.2005, p. 95-100.

Research output: Contribution to journalArticle

Tsou, Tai Li ; Tang, Shang Tao ; Huang, Yu Chuan ; Wu, Jing Ran ; Young, Jenn Jong ; Wang, Hsian-Jenn. / Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies. In: Journal of Materials Science: Materials in Medicine. 2005 ; Vol. 16, No. 2. pp. 95-100.
@article{f073bdd501834d3baf3e02a89649fba3,
title = "Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies",
abstract = "An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0{\%} (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8{\%}. In the ranges of 0 ≤ F ≤ 0.6, the n value of 1{\%}CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8{\%} of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1{\%} CIP-pHEMA membrane (cross-linked with 4{\%} EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.",
author = "Tsou, {Tai Li} and Tang, {Shang Tao} and Huang, {Yu Chuan} and Wu, {Jing Ran} and Young, {Jenn Jong} and Hsian-Jenn Wang",
year = "2005",
month = "2",
day = "1",
doi = "10.1007/s10856-005-5954-2",
language = "English",
volume = "16",
pages = "95--100",
journal = "Journal of Materials Science: Materials in Medicine",
issn = "0957-4522",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies

AU - Tsou, Tai Li

AU - Tang, Shang Tao

AU - Huang, Yu Chuan

AU - Wu, Jing Ran

AU - Young, Jenn Jong

AU - Wang, Hsian-Jenn

PY - 2005/2/1

Y1 - 2005/2/1

N2 - An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0 ≤ F ≤ 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.

AB - An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0 ≤ F ≤ 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.

UR - http://www.scopus.com/inward/record.url?scp=15244357598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15244357598&partnerID=8YFLogxK

U2 - 10.1007/s10856-005-5954-2

DO - 10.1007/s10856-005-5954-2

M3 - Article

C2 - 15744596

AN - SCOPUS:15244357598

VL - 16

SP - 95

EP - 100

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 0957-4522

IS - 2

ER -