Poly-Methyl Methacrylate/Polyvinyl Alcohol Copolymer Agents Applied on Diabetic Wound Dressing

Hsiao Ting Hsieh, Hung Ming Chang, Wei Jhih Lin, Yao Tsung Hsu, Fu Der Mai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Due to the difficulty of healing chronic wound, in the process of changing dressing, secondary damage on the tissue caused by adhesion should be prevented. In this study, the new dressing of particle hydrogels synthesized with poly-methyl methacrylate and poly-vinyl alcohol precursors were proposed. In addition, cell safety tests, animal's allergic stimulation, and animal's wound healing experiments were conducted for particle hydrogels. On one hand, in L929 cell experiment, the results of particle hydrogels extract 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide tests and lactate dehydrogenase test trial show that there are no safety concerns over particle hydrogels. On the other hand, New Zealand white rabbits were chosen for skin sensitization tests in animal trials, which show the consistent results. At last, wound healing tests used diabetes induction with 10-week-old rats and three-month-old Landrace pigs, with the tissue histology. In short, through this experiment, it is found that in the early phase of the diabetic rats and pigs' wound healing, using particle hydrogels can enhance collagen formation, and achieve the goal of faster wound healing.

Original languageEnglish
Article number9531
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Polyvinyl alcohols
Polymethyl methacrylates
Hydrogels
Particles (particulate matter)
Copolymers
Animals
Rats
Tissue
Histology
Experiments
Medical problems
Collagen
Skin
Alcohols
Adhesion

ASJC Scopus subject areas

  • General

Cite this

Poly-Methyl Methacrylate/Polyvinyl Alcohol Copolymer Agents Applied on Diabetic Wound Dressing. / Hsieh, Hsiao Ting; Chang, Hung Ming; Lin, Wei Jhih; Hsu, Yao Tsung; Mai, Fu Der.

In: Scientific Reports, Vol. 7, No. 1, 9531, 01.12.2017.

Research output: Contribution to journalArticle

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