Point-of-care detection and real-time monitoring of intravenously delivered drugs via tubing with an integrated SERS sensor

Hsin Yu Wu, Brian T. Cunningham

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We demonstrate an approach for detection, identification, and kinetic monitoring of drugs flowing within tubing, through the use of a plasmonic nanodome array (PNA) surface. The PNA structures are fabricated using a low-cost nanoreplica molding process upon a flexible plastic substrate that is subsequently integrated with a flow cell that connects in series with ordinary intravenous (IV) drug delivery tubing. To investigate the potential clinical applications for point-of-care detection and real-time monitoring, we perform SERS detection of ten pharmaceutical compounds (hydrocodone, levorphanol, morphine, oxycodone, methadone, phenobarbital, dopamine, diltiazem, promethazine, and mitoxantrone). We demonstrate dose-dependent SERS signal magnitude, resulting in detection limits (ng ml-1) well below typical administered dosages (mg ml-1). Further, we show that the detected drugs are not permanently attached to the PNA surface, and thus our approach is capable of performing continuous monitoring of drug delivery as materials flow through IV tubing that is connected in series with the sensor. Finally, we demonstrate the potential co-detection of multiple drugs when they are mixed together, and show excellent reproducibility and stability of SERS measurements for periods extending at least five days. The capabilities reported here demonstrate the potential to use PNA SERS surfaces for enhancing the safety of IV drug delivery. This journal is

Original languageEnglish
Pages (from-to)5162-5171
Number of pages10
JournalNanoscale
Volume6
Issue number10
DOIs
Publication statusPublished - May 21 2014
Externally publishedYes

Fingerprint

Point-of-Care Systems
Tubing
Drug delivery
Monitoring
Sensors
Pharmaceutical Preparations
Drug Monitoring
Levorphanol
Hydrocodone
Oxycodone
Promethazine
Molding
Mitoxantrone
Drug products
Diltiazem
Methadone
Phenobarbital
Morphine
Plastics
Dopamine

ASJC Scopus subject areas

  • Materials Science(all)
  • Medicine(all)

Cite this

Point-of-care detection and real-time monitoring of intravenously delivered drugs via tubing with an integrated SERS sensor. / Wu, Hsin Yu; Cunningham, Brian T.

In: Nanoscale, Vol. 6, No. 10, 21.05.2014, p. 5162-5171.

Research output: Contribution to journalArticle

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