Podophyllotoxin intoxication: Toxic effect of Bajiaolian in herbal therapeutics

W. F. Kao, D. Z. Hung, W. J. Tsai, K. P. Lin, J. F. Deng

Research output: Contribution to journalArticle

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Abstract

Bajiaolian (Dysosma pleianthum), one species in the Mayapple family, has been widely used as a general remedy and for the treatment of snake bite, weakness, condyloma accuminata, lymphadenopathy and tumours in China for thousands of years. However, the textbooks of traditional Chinese medicine mention little about the toxicity of Bajiaolian. Within 1 year, the authors saw five people who manifested nausea, vomiting, diarrhoea, abdominal pain, thrombocytopenia, leucopenia, abnormal liver function tests, sensory ataxia, altered consciousness and persistant peripheral tingling or numbness after drinking infusions made with Bajiaolian. The herb was recommended by either traditional Chinese medical doctors or herbal pharmacies for postpartum recovery and treatment of a neck mass, hepatoma, lumbago and dysmenorrhoea. Podophyllotoxin is one of the main ingredients of the Bajiaolian root. The clinical manifestations observed in our patients were consistent with podophyllum intoxication. Podophyllotoxin intoxication usually results from the accidental ingestion or topical application of podophyllum resin. However, these cases of Bajiaolian intoxication were iatrogenic and results from 'therapeutic doses' of Bajiaolian cited in the textbooks of traditional Chinese medicine.

Original languageEnglish
Pages (from-to)480-487
Number of pages8
JournalHuman and Experimental Toxicology
Volume11
Issue number6
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Podophyllotoxin
Textbooks
Poisons
Medicine
Podophyllin
Chinese Traditional Medicine
Podophyllum peltatum
Podophyllum
Liver
Toxicity
Snake Bites
Tumors
Dysmenorrhea
Hypesthesia
Pharmacies
Liver Function Tests
Leukopenia
Ataxia
Low Back Pain
Consciousness

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Kao, W. F., Hung, D. Z., Tsai, W. J., Lin, K. P., & Deng, J. F. (1992). Podophyllotoxin intoxication: Toxic effect of Bajiaolian in herbal therapeutics. Human and Experimental Toxicology, 11(6), 480-487.

Podophyllotoxin intoxication : Toxic effect of Bajiaolian in herbal therapeutics. / Kao, W. F.; Hung, D. Z.; Tsai, W. J.; Lin, K. P.; Deng, J. F.

In: Human and Experimental Toxicology, Vol. 11, No. 6, 1992, p. 480-487.

Research output: Contribution to journalArticle

Kao, WF, Hung, DZ, Tsai, WJ, Lin, KP & Deng, JF 1992, 'Podophyllotoxin intoxication: Toxic effect of Bajiaolian in herbal therapeutics', Human and Experimental Toxicology, vol. 11, no. 6, pp. 480-487.
Kao, W. F. ; Hung, D. Z. ; Tsai, W. J. ; Lin, K. P. ; Deng, J. F. / Podophyllotoxin intoxication : Toxic effect of Bajiaolian in herbal therapeutics. In: Human and Experimental Toxicology. 1992 ; Vol. 11, No. 6. pp. 480-487.
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