Podophyllin, but not the constituents quercetin or kaempferol, induced genotoxicity in vitro and in vivo through ROS production

Mei Chih Lin, Hui Wen Cheng, Yi Chen Tsai, Po Lin Liao, Jaw Jou Kang, Yu Wen Cheng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The genotoxic potential of podophyllin (PD) was investigated in this study. PD increased bacterial revertants and abnormal chromosomal structures in a concentration-dependent manner, both with and without metabolic activating enzymes, and increased the incidence of micronuclei in imprinted control region mouse reticulocytes. Results from three studied constituents of PD, such as podophyllotoxin, kampferol, and quercetin, suggested that the mutagenic effect of PD was not due to the presence of podophyllotoxin, kampferol, and quercetin and might be related to other components and the formation of reactive oxygen species. The detailed mutagenic mechanisms need further investigation, and the medicinal use of PD needs to be cautioned against.

Original languageEnglish
Pages (from-to)68-76
Number of pages9
JournalDrug and Chemical Toxicology
Volume32
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Ames test
  • Chromosome aberration
  • Genotoxicity
  • Micronucleus
  • Podophyllin
  • Reactive oxygen Species
  • Reactive oxygen species

ASJC Scopus subject areas

  • Chemical Health and Safety
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Pharmacology
  • Toxicology

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