Pneumocystis carinii pneumonia in systemic lupus erythematosus: A report of two cases

H. C. Tsai, S. S J Lee, H. H. Lin, L. Y. Lu, Y. C. Liu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Patients with systemic lupus eythematosus (SLE) have increased susceptibility to infection by Pneumocystis carinii, but this condition has rarely been reported in Taiwan. Here, we describe two cases of patients with SLE who developed Pneumocystis carinii pneumonia (PCP). The first patient was a 39-year-old woman presenting with fever and dyspnea that had lasted 2 weeks. Chest roentgenography disclosed bilateral interstitial and alveolar infiltrates. The second patient was a 22-year-old woman presenting with a 4-day history of malaise, cough, dyspnea, and fever. She had concomitant Mycobacterium tuberculosis infection. Both patients had been treated with varying doses of corticosteroids and/or cytotoxic drugs within 4 months before presentation. Diagnosis was established based on the findings of bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB). Both patients received trimethoprim-sulfamethoxazole (20 mg·kg-1·d-1 trimethoprim), but finally died of nosocomial septicemia (Acinetobacter baumanni and Pseudomonas aeruginosa bacteremia in one, P. aeruginosa bacteremia in the other). These two cases demonstrate that PCP should be included in the differential diagnosis of patients with SLE presenting with pneumonic processes. In addition, a second opportunistic pathogen should be suspected. Bronchoscopic examination should be performed if the diagnosis is not clear and should include TBLB and BAL.

Original languageEnglish
Pages (from-to)699-702
Number of pages4
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume100
Issue number10
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Pneumocystis Pneumonia
Systemic Lupus Erythematosus
Bronchoalveolar Lavage
Bacteremia
Dyspnea
Pseudomonas aeruginosa
Fever
Pneumocystis Infections
Biopsy
Lung
Mycobacterium Infections
Acinetobacter
Trimethoprim
Sulfamethoxazole Drug Combination Trimethoprim
Taiwan
Mycobacterium tuberculosis
Cough
Radiography
Sepsis
Adrenal Cortex Hormones

Keywords

  • Pneumocystis carinii pneumonia
  • Systemic lupus erythematosus
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pneumocystis carinii pneumonia in systemic lupus erythematosus : A report of two cases. / Tsai, H. C.; Lee, S. S J; Lin, H. H.; Lu, L. Y.; Liu, Y. C.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 100, No. 10, 2001, p. 699-702.

Research output: Contribution to journalArticle

@article{14672ddcb64343de9682e6ba3338d704,
title = "Pneumocystis carinii pneumonia in systemic lupus erythematosus: A report of two cases",
abstract = "Patients with systemic lupus eythematosus (SLE) have increased susceptibility to infection by Pneumocystis carinii, but this condition has rarely been reported in Taiwan. Here, we describe two cases of patients with SLE who developed Pneumocystis carinii pneumonia (PCP). The first patient was a 39-year-old woman presenting with fever and dyspnea that had lasted 2 weeks. Chest roentgenography disclosed bilateral interstitial and alveolar infiltrates. The second patient was a 22-year-old woman presenting with a 4-day history of malaise, cough, dyspnea, and fever. She had concomitant Mycobacterium tuberculosis infection. Both patients had been treated with varying doses of corticosteroids and/or cytotoxic drugs within 4 months before presentation. Diagnosis was established based on the findings of bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB). Both patients received trimethoprim-sulfamethoxazole (20 mg·kg-1·d-1 trimethoprim), but finally died of nosocomial septicemia (Acinetobacter baumanni and Pseudomonas aeruginosa bacteremia in one, P. aeruginosa bacteremia in the other). These two cases demonstrate that PCP should be included in the differential diagnosis of patients with SLE presenting with pneumonic processes. In addition, a second opportunistic pathogen should be suspected. Bronchoscopic examination should be performed if the diagnosis is not clear and should include TBLB and BAL.",
keywords = "Pneumocystis carinii pneumonia, Systemic lupus erythematosus, Tuberculosis",
author = "Tsai, {H. C.} and Lee, {S. S J} and Lin, {H. H.} and Lu, {L. Y.} and Liu, {Y. C.}",
year = "2001",
language = "English",
volume = "100",
pages = "699--702",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "10",

}

TY - JOUR

T1 - Pneumocystis carinii pneumonia in systemic lupus erythematosus

T2 - A report of two cases

AU - Tsai, H. C.

AU - Lee, S. S J

AU - Lin, H. H.

AU - Lu, L. Y.

AU - Liu, Y. C.

PY - 2001

Y1 - 2001

N2 - Patients with systemic lupus eythematosus (SLE) have increased susceptibility to infection by Pneumocystis carinii, but this condition has rarely been reported in Taiwan. Here, we describe two cases of patients with SLE who developed Pneumocystis carinii pneumonia (PCP). The first patient was a 39-year-old woman presenting with fever and dyspnea that had lasted 2 weeks. Chest roentgenography disclosed bilateral interstitial and alveolar infiltrates. The second patient was a 22-year-old woman presenting with a 4-day history of malaise, cough, dyspnea, and fever. She had concomitant Mycobacterium tuberculosis infection. Both patients had been treated with varying doses of corticosteroids and/or cytotoxic drugs within 4 months before presentation. Diagnosis was established based on the findings of bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB). Both patients received trimethoprim-sulfamethoxazole (20 mg·kg-1·d-1 trimethoprim), but finally died of nosocomial septicemia (Acinetobacter baumanni and Pseudomonas aeruginosa bacteremia in one, P. aeruginosa bacteremia in the other). These two cases demonstrate that PCP should be included in the differential diagnosis of patients with SLE presenting with pneumonic processes. In addition, a second opportunistic pathogen should be suspected. Bronchoscopic examination should be performed if the diagnosis is not clear and should include TBLB and BAL.

AB - Patients with systemic lupus eythematosus (SLE) have increased susceptibility to infection by Pneumocystis carinii, but this condition has rarely been reported in Taiwan. Here, we describe two cases of patients with SLE who developed Pneumocystis carinii pneumonia (PCP). The first patient was a 39-year-old woman presenting with fever and dyspnea that had lasted 2 weeks. Chest roentgenography disclosed bilateral interstitial and alveolar infiltrates. The second patient was a 22-year-old woman presenting with a 4-day history of malaise, cough, dyspnea, and fever. She had concomitant Mycobacterium tuberculosis infection. Both patients had been treated with varying doses of corticosteroids and/or cytotoxic drugs within 4 months before presentation. Diagnosis was established based on the findings of bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB). Both patients received trimethoprim-sulfamethoxazole (20 mg·kg-1·d-1 trimethoprim), but finally died of nosocomial septicemia (Acinetobacter baumanni and Pseudomonas aeruginosa bacteremia in one, P. aeruginosa bacteremia in the other). These two cases demonstrate that PCP should be included in the differential diagnosis of patients with SLE presenting with pneumonic processes. In addition, a second opportunistic pathogen should be suspected. Bronchoscopic examination should be performed if the diagnosis is not clear and should include TBLB and BAL.

KW - Pneumocystis carinii pneumonia

KW - Systemic lupus erythematosus

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=0035198416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035198416&partnerID=8YFLogxK

M3 - Article

C2 - 11760377

AN - SCOPUS:0035198416

VL - 100

SP - 699

EP - 702

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 10

ER -