Pneumococcal meningitis in Taiwanese children: Emphasis on clinical outcomes and prognostic factors

Ming Han Tsai, Shih Hsiang Chen, Chih Yi Hsu, Dah Chin Yan, Meng Hsiu Yen, Cheng Hsun Chiu, Yhu Chering Huang, Tzou Yien Lin

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Pneumococcal meningitis causes high morbidity or mortality in childhood despite the progress in medicine. Children with pneumococcal meningitis were identified and retrospectively reviewed. Forty-nine children were eligible, with mortality in 24.5% of all and neurological sequelae in 40.5% of survivors. In the analysis of clinical profiles, ventilator support (p = 0.001), septic shock (p < 0.001), multiple organ failure (p < 0.001) and lower cerebrospinal fluid (CSF) leukocyte count (p = 0.001) were more frequently found in non-survivors. Besides, CSF protein (p = 0.006) was higher in survivors with neurological sequelae. Initial dexamethasone usage and disease severity did not affect the occurrence of neurological sequelae. Multivariate logistic regression analysis revealed that CSF leukocyte count ≤ 200 mm-3 (p = 0.013) and protein level ≥ 330 g l-1 (p = 0.022) were significantly risk factors associated with poor outcomes, and physicians should be cautious if such conditions occur.

Original languageEnglish
Pages (from-to)390-394
Number of pages5
JournalJournal of Tropical Pediatrics
Volume54
Issue number6
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Children
  • Meningitis
  • Outcomes
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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