Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts

Hui Chin Peng, Ming Te Huang, Da Jeng Chen, Ting-Kai Leung, Jan Show Chu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a rare, nonmetastasizing tumor of uncertain lineage which was first reported in 1996. Here, we report a case of PHAT and review the literature. A 49-year-old man presented with a soft and progressively enlarging mass over the right buttock for several years. On suspicion that the mass was a right gluteal lipoma, he underwent surgical excision. The excised lesion measured 14 × 6 × 3.5 cm. It had a variegated appearance with a white-tan to yellowish color on the cut surface. Some punctate hemorrhage and vessel thrombosis were seen. Microscopically, the tumor was a PHAT characterized by clusters of ectatic, fibrin-lined, thin-walled vessels, which were surrounded by a mitotically inert, spindled, pleomorphic, neoplastic stroma that contained a variable inflammatory component. Immunohistochemical study showed that the tumor cells were positive for CD34, and negative for S-100, HMB45 and actin. The patient experienced local recurrence 6 months later. The recurrent tumor was widely excised. No evidence of metastasis was found during the 18 months after the second operation. The recurrent lesion had a microscopic appearance that was similar to the initial lesion.

Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume109
Issue number8
DOIs
Publication statusPublished - 2010

Fingerprint

Neoplasms
Buttocks
Lipoma
Fibrin
Actins
Thrombosis
Color
Hemorrhage
Neoplasm Metastasis
Recurrence

Keywords

  • Pleomorphic hyalinizing angiectatic tumor
  • Soft tissue tumor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts. / Peng, Hui Chin; Huang, Ming Te; Chen, Da Jeng; Leung, Ting-Kai; Chu, Jan Show.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 109, No. 8, 2010, p. 616-620.

Research output: Contribution to journalArticle

@article{ce567b2ab2eb4431a62d9869268d2dc0,
title = "Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts",
abstract = "Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a rare, nonmetastasizing tumor of uncertain lineage which was first reported in 1996. Here, we report a case of PHAT and review the literature. A 49-year-old man presented with a soft and progressively enlarging mass over the right buttock for several years. On suspicion that the mass was a right gluteal lipoma, he underwent surgical excision. The excised lesion measured 14 × 6 × 3.5 cm. It had a variegated appearance with a white-tan to yellowish color on the cut surface. Some punctate hemorrhage and vessel thrombosis were seen. Microscopically, the tumor was a PHAT characterized by clusters of ectatic, fibrin-lined, thin-walled vessels, which were surrounded by a mitotically inert, spindled, pleomorphic, neoplastic stroma that contained a variable inflammatory component. Immunohistochemical study showed that the tumor cells were positive for CD34, and negative for S-100, HMB45 and actin. The patient experienced local recurrence 6 months later. The recurrent tumor was widely excised. No evidence of metastasis was found during the 18 months after the second operation. The recurrent lesion had a microscopic appearance that was similar to the initial lesion.",
keywords = "Pleomorphic hyalinizing angiectatic tumor, Soft tissue tumor",
author = "Peng, {Hui Chin} and Huang, {Ming Te} and Chen, {Da Jeng} and Ting-Kai Leung and Chu, {Jan Show}",
year = "2010",
doi = "10.1016/S0929-6646(10)60100-3",
language = "English",
volume = "109",
pages = "616--620",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "8",

}

TY - JOUR

T1 - Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts

AU - Peng, Hui Chin

AU - Huang, Ming Te

AU - Chen, Da Jeng

AU - Leung, Ting-Kai

AU - Chu, Jan Show

PY - 2010

Y1 - 2010

N2 - Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a rare, nonmetastasizing tumor of uncertain lineage which was first reported in 1996. Here, we report a case of PHAT and review the literature. A 49-year-old man presented with a soft and progressively enlarging mass over the right buttock for several years. On suspicion that the mass was a right gluteal lipoma, he underwent surgical excision. The excised lesion measured 14 × 6 × 3.5 cm. It had a variegated appearance with a white-tan to yellowish color on the cut surface. Some punctate hemorrhage and vessel thrombosis were seen. Microscopically, the tumor was a PHAT characterized by clusters of ectatic, fibrin-lined, thin-walled vessels, which were surrounded by a mitotically inert, spindled, pleomorphic, neoplastic stroma that contained a variable inflammatory component. Immunohistochemical study showed that the tumor cells were positive for CD34, and negative for S-100, HMB45 and actin. The patient experienced local recurrence 6 months later. The recurrent tumor was widely excised. No evidence of metastasis was found during the 18 months after the second operation. The recurrent lesion had a microscopic appearance that was similar to the initial lesion.

AB - Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a rare, nonmetastasizing tumor of uncertain lineage which was first reported in 1996. Here, we report a case of PHAT and review the literature. A 49-year-old man presented with a soft and progressively enlarging mass over the right buttock for several years. On suspicion that the mass was a right gluteal lipoma, he underwent surgical excision. The excised lesion measured 14 × 6 × 3.5 cm. It had a variegated appearance with a white-tan to yellowish color on the cut surface. Some punctate hemorrhage and vessel thrombosis were seen. Microscopically, the tumor was a PHAT characterized by clusters of ectatic, fibrin-lined, thin-walled vessels, which were surrounded by a mitotically inert, spindled, pleomorphic, neoplastic stroma that contained a variable inflammatory component. Immunohistochemical study showed that the tumor cells were positive for CD34, and negative for S-100, HMB45 and actin. The patient experienced local recurrence 6 months later. The recurrent tumor was widely excised. No evidence of metastasis was found during the 18 months after the second operation. The recurrent lesion had a microscopic appearance that was similar to the initial lesion.

KW - Pleomorphic hyalinizing angiectatic tumor

KW - Soft tissue tumor

UR - http://www.scopus.com/inward/record.url?scp=77956635841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956635841&partnerID=8YFLogxK

U2 - 10.1016/S0929-6646(10)60100-3

DO - 10.1016/S0929-6646(10)60100-3

M3 - Article

C2 - 20708514

AN - SCOPUS:77956635841

VL - 109

SP - 616

EP - 620

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 8

ER -