Plectranthus amboinicus and Centella asiatica cream for the treatment of diabetic foot ulcers

Yuan-Sung Kuo, Hsiung-Fei Chien, William Lu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness. Copyright © 2012 Yuan-Sung Kuo et al.
Original languageEnglish
JournalEvidence-based Complementary and Alternative Medicine
Volume2012
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Plectranthus
Hydrocolloid Bandages
Centella
Diabetic Foot
Wounds and Injuries
Apiaceae
Foot Ulcer
Lamiaceae
Colloids
Debridement
Therapeutics
Bandages
Type 2 Diabetes Mellitus
Safety

Keywords

  • Centella asiatica extract
  • opsite
  • plant extract
  • Plectranthus amboinicus extract
  • unclassified drug
  • adult
  • aged
  • article
  • Centella asiatica
  • clinical article
  • constipation
  • controlled study
  • cream
  • debridement
  • diabetic foot
  • dizziness
  • drug dosage form comparison
  • female
  • human
  • hydrocolloid dressing
  • hypoglycemia
  • insulin dependent diabetes mellitus
  • male
  • non insulin dependent diabetes mellitus
  • Plectranthus
  • Plectranthus amboinicus
  • priority journal
  • randomized controlled trial
  • safety
  • tinea pedis
  • visual field defect
  • wound dressing

Cite this

@article{cf09daed4ae04065bbc58932302944e1,
title = "Plectranthus amboinicus and Centella asiatica cream for the treatment of diabetic foot ulcers",
abstract = "Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness. Copyright {\circledC} 2012 Yuan-Sung Kuo et al.",
keywords = "Centella asiatica extract, opsite, plant extract, Plectranthus amboinicus extract, unclassified drug, adult, aged, article, Centella asiatica, clinical article, constipation, controlled study, cream, debridement, diabetic foot, dizziness, drug dosage form comparison, female, human, hydrocolloid dressing, hypoglycemia, insulin dependent diabetes mellitus, male, non insulin dependent diabetes mellitus, Plectranthus, Plectranthus amboinicus, priority journal, randomized controlled trial, safety, tinea pedis, visual field defect, wound dressing",
author = "Yuan-Sung Kuo and Hsiung-Fei Chien and William Lu",
note = "Export Date: 16 March 2016 通訊地址: Chien, H.-F.; Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan; 電子郵件: hfchien@ntu.edu.tw 商標: AQUACEL; Opsite, Smith and Nephew, Taiwan 製造商: Smith and Nephew, Taiwan 參考文獻: Frykberg, R.G., Diabetic foot ulcers: Pathogenesis and management (2002) American Family Physician, 66 (9), pp. 1655-1662; Bader, M.S., Diabetic foot infection (2008) American Family Physician, 78 (1), pp. 71-79; Reiber, G.E., Smith, D.G., Vileikyte, L., Lavery, L.A., Boyko, E.J., Boulton, A.J.M., Del Aguila, M., Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings (1999) Diabetes Care, 22 (1), pp. 157-162. , DOI 10.2337/diacare.22.1.157; Frykberg, R.G., Wittmayer, B., Zgonis, T., Surgical Management of Diabetic Foot Infections and Osteomyelitis (2007) Clinics in Podiatric Medicine and Surgery, 24 (3), pp. 469-482. , DOI 10.1016/j.cpm.2007.04.001, PII S0891842207000316, Advances in the Treatment of the Diabetic Foot; Lipsky, B.A., Berendt, A.R., Deery, H.G., Embil, J.M., Joseph, W.S., Karchmer, A.W., LeFrock, J.L., Tan, J.S., Diagnosis and treatment of diabetic foot infections (2004) Clinical Infectious Diseases, 39 (7), pp. 885-910. , DOI 10.1086/424846; Lipsky, B.A., Armstrong, D.G., Citron, D.M., Tice, A.D., Morgenstern, D.E., Abramson, M.A., Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): Prospective, randomised, controlled, double-blinded, multicentre trial (2005) Lancet, 366 (9498), pp. 1695-1703. , DOI 10.1016/S0140-6736(05)67694-5, PII S0140673605676945; Lipsky, B.A., Giordano, P., Choudhri, S., Song, J., Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/ amoxicillin-clavulanate (2007) Journal of Antimicrobial Chemotherapy, 60 (2), pp. 370-376. , DOI 10.1093/jac/dkm130; Nagoba, B.S., Gandhi, R.C., Wadher, B.J., Rao, A., Hartalkar, A.R., Selkar, S.P., A simple and effective approach for the treatment of diabetic foot ulcers with different Wagner grades (2010) International Wound Journal, 7 (3), pp. 153-158; Chen, L.C., Wang, B.R., Chou, Y.C., Tien, J.H., Drug utilization pattern of Chinese herbal medicines in a general hospital in Taiwan (2005) Pharmacoepidemiology and Drug Safety, 14 (9), pp. 651-657. , DOI 10.1002/pds.1087; Lukhoba, C.W., Simmonds, M.S.J., Paton, A.J., Plectranthus: A review of ethnobotanical uses (2006) Journal of Ethnopharmacology, 103 (1), pp. 1-24. , DOI 10.1016/j.jep.2005.09.011, PII S0378874105006215; Gurgel, A.P.A.D., Da Silva, J.G., Grangeiro, A.R.S., Oliveira, D.C., Lima, C.M.P., Da Silva, A.C.P., Oliveira, R.A.G., Souza, I.A., In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae) (2009) Journal of Ethnopharmacology, 125 (2), pp. 361-363; Chiu, Y.J., Huang, T.H., Chiu, C.S., Analgesic and antiinflammatory activities of the aqueous extract from Plectranthus amboinicus (Lour.) Spreng. Both in vitro and in vivo (2012) Evidence-Based Complementary and Alternative Medicine, 2012, p. 11; Shukla, A., Rasik, A.M., Jain, G.K., Shankar, R., Kulshrestha, D.K., Dhawan, B.N., In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica (1999) Journal of Ethnopharmacology, 65 (1), pp. 1-11. , DOI 10.1016/S0378-8741(98)00141-X, PII S037887419800141X; Brinkhaus, B., Lindner, M., Schuppan, D., Hahn, E.G., Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica (2000) Phytomedicine, 7 (5), pp. 427-448; Piaggesi, A., Baccetti, F., Rizzo, L., Romanelli, M., Navalesi, R., Benzi, L., Sodium carboxyl-methyl-cellulose dressings in the management of deep ulcerations of diabetic foot (2001) Diabetic Medicine, 18 (4), pp. 320-324. , DOI 10.1046/j.1464-5491.2001.00466.x; Jeffcoate, W.J., Price, P.E., Phillips, C.J., Game, F.L., Mudge, E., Davies, S., Amery, C.M., Harding, K.G., Randomised controlled trial of the use of three dressing preparations in the management of chronic ulceration of the foot in diabetes (2009) Health Technology Assessment, 13 (54), pp. 1-86; Brown-Etris, M., Milne, C., Orsted, H., Gates, J.L., Netsch, D., Punchello, M., Couture, N., Freyberg, J., A prospective, randomized, multisite clinical evaluation of a transparent absorbent acrylic dressing and a hydrocolloid dressing in the management of Stage II and shallow Stage III pressure ulcers (2008) Advances in Skin Wound Care, 21 (4), pp. 169-174; Ernst, E., Cardiovascular adverse effects of herbal medicines: A systematic review of the recent litarature (2003) Canadian Journal of Cardiology, 19 (7), pp. 818-827; Ernst, E., Herbal medicines: Balancing benefits and risks (2007) Novartis Foundation Symposium, 282, pp. 154-167; Lavery, L.A., Armstrong, D.G., Harkless, L.B., Classification of diabetic foot wounds (1996) Journal of Foot and Ankle Surgery, 35 (6), pp. 528-531; Mustoe, T.A., Cutler, N.R., Allman, R.M., Goode, P.S., Deuel, T.F., Prause, J.A., Bear, M., Pierce, G.F., A phase II study to evaluate recombinant platelet-derived growth factor- BB in the treatment of stage 3 and 4 pressure ulcers (1994) Archives of Surgery, 129 (2), pp. 213-219; Wieman, T.J., Smiell, J.M., Su, Y., Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers: A phase III randomized placebo-controlled double-blind study (1998) Diabetes Care, 21 (5), pp. 822-827. , DOI 10.2337/diacare.21.5.822; Shukrimi, A., Sulaiman, A.R., Halim, A.Y., Azril, A., A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers (2008) Medical Journal of Malaysia, 63 (1), pp. 44-46",
year = "2012",
doi = "10.1155/2012/418679",
language = "English",
volume = "2012",
journal = "Evidence-based Complementary and Alternative Medicine",
issn = "1741-427X",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Plectranthus amboinicus and Centella asiatica cream for the treatment of diabetic foot ulcers

AU - Kuo, Yuan-Sung

AU - Chien, Hsiung-Fei

AU - Lu, William

N1 - Export Date: 16 March 2016 通訊地址: Chien, H.-F.; Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan; 電子郵件: hfchien@ntu.edu.tw 商標: AQUACEL; Opsite, Smith and Nephew, Taiwan 製造商: Smith and Nephew, Taiwan 參考文獻: Frykberg, R.G., Diabetic foot ulcers: Pathogenesis and management (2002) American Family Physician, 66 (9), pp. 1655-1662; Bader, M.S., Diabetic foot infection (2008) American Family Physician, 78 (1), pp. 71-79; Reiber, G.E., Smith, D.G., Vileikyte, L., Lavery, L.A., Boyko, E.J., Boulton, A.J.M., Del Aguila, M., Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings (1999) Diabetes Care, 22 (1), pp. 157-162. , DOI 10.2337/diacare.22.1.157; Frykberg, R.G., Wittmayer, B., Zgonis, T., Surgical Management of Diabetic Foot Infections and Osteomyelitis (2007) Clinics in Podiatric Medicine and Surgery, 24 (3), pp. 469-482. , DOI 10.1016/j.cpm.2007.04.001, PII S0891842207000316, Advances in the Treatment of the Diabetic Foot; Lipsky, B.A., Berendt, A.R., Deery, H.G., Embil, J.M., Joseph, W.S., Karchmer, A.W., LeFrock, J.L., Tan, J.S., Diagnosis and treatment of diabetic foot infections (2004) Clinical Infectious Diseases, 39 (7), pp. 885-910. , DOI 10.1086/424846; Lipsky, B.A., Armstrong, D.G., Citron, D.M., Tice, A.D., Morgenstern, D.E., Abramson, M.A., Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): Prospective, randomised, controlled, double-blinded, multicentre trial (2005) Lancet, 366 (9498), pp. 1695-1703. , DOI 10.1016/S0140-6736(05)67694-5, PII S0140673605676945; Lipsky, B.A., Giordano, P., Choudhri, S., Song, J., Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/ amoxicillin-clavulanate (2007) Journal of Antimicrobial Chemotherapy, 60 (2), pp. 370-376. , DOI 10.1093/jac/dkm130; Nagoba, B.S., Gandhi, R.C., Wadher, B.J., Rao, A., Hartalkar, A.R., Selkar, S.P., A simple and effective approach for the treatment of diabetic foot ulcers with different Wagner grades (2010) International Wound Journal, 7 (3), pp. 153-158; Chen, L.C., Wang, B.R., Chou, Y.C., Tien, J.H., Drug utilization pattern of Chinese herbal medicines in a general hospital in Taiwan (2005) Pharmacoepidemiology and Drug Safety, 14 (9), pp. 651-657. , DOI 10.1002/pds.1087; Lukhoba, C.W., Simmonds, M.S.J., Paton, A.J., Plectranthus: A review of ethnobotanical uses (2006) Journal of Ethnopharmacology, 103 (1), pp. 1-24. , DOI 10.1016/j.jep.2005.09.011, PII S0378874105006215; Gurgel, A.P.A.D., Da Silva, J.G., Grangeiro, A.R.S., Oliveira, D.C., Lima, C.M.P., Da Silva, A.C.P., Oliveira, R.A.G., Souza, I.A., In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae) (2009) Journal of Ethnopharmacology, 125 (2), pp. 361-363; Chiu, Y.J., Huang, T.H., Chiu, C.S., Analgesic and antiinflammatory activities of the aqueous extract from Plectranthus amboinicus (Lour.) Spreng. Both in vitro and in vivo (2012) Evidence-Based Complementary and Alternative Medicine, 2012, p. 11; Shukla, A., Rasik, A.M., Jain, G.K., Shankar, R., Kulshrestha, D.K., Dhawan, B.N., In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica (1999) Journal of Ethnopharmacology, 65 (1), pp. 1-11. , DOI 10.1016/S0378-8741(98)00141-X, PII S037887419800141X; Brinkhaus, B., Lindner, M., Schuppan, D., Hahn, E.G., Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica (2000) Phytomedicine, 7 (5), pp. 427-448; Piaggesi, A., Baccetti, F., Rizzo, L., Romanelli, M., Navalesi, R., Benzi, L., Sodium carboxyl-methyl-cellulose dressings in the management of deep ulcerations of diabetic foot (2001) Diabetic Medicine, 18 (4), pp. 320-324. , DOI 10.1046/j.1464-5491.2001.00466.x; Jeffcoate, W.J., Price, P.E., Phillips, C.J., Game, F.L., Mudge, E., Davies, S., Amery, C.M., Harding, K.G., Randomised controlled trial of the use of three dressing preparations in the management of chronic ulceration of the foot in diabetes (2009) Health Technology Assessment, 13 (54), pp. 1-86; Brown-Etris, M., Milne, C., Orsted, H., Gates, J.L., Netsch, D., Punchello, M., Couture, N., Freyberg, J., A prospective, randomized, multisite clinical evaluation of a transparent absorbent acrylic dressing and a hydrocolloid dressing in the management of Stage II and shallow Stage III pressure ulcers (2008) Advances in Skin Wound Care, 21 (4), pp. 169-174; Ernst, E., Cardiovascular adverse effects of herbal medicines: A systematic review of the recent litarature (2003) Canadian Journal of Cardiology, 19 (7), pp. 818-827; Ernst, E., Herbal medicines: Balancing benefits and risks (2007) Novartis Foundation Symposium, 282, pp. 154-167; Lavery, L.A., Armstrong, D.G., Harkless, L.B., Classification of diabetic foot wounds (1996) Journal of Foot and Ankle Surgery, 35 (6), pp. 528-531; Mustoe, T.A., Cutler, N.R., Allman, R.M., Goode, P.S., Deuel, T.F., Prause, J.A., Bear, M., Pierce, G.F., A phase II study to evaluate recombinant platelet-derived growth factor- BB in the treatment of stage 3 and 4 pressure ulcers (1994) Archives of Surgery, 129 (2), pp. 213-219; Wieman, T.J., Smiell, J.M., Su, Y., Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers: A phase III randomized placebo-controlled double-blind study (1998) Diabetes Care, 21 (5), pp. 822-827. , DOI 10.2337/diacare.21.5.822; Shukrimi, A., Sulaiman, A.R., Halim, A.Y., Azril, A., A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers (2008) Medical Journal of Malaysia, 63 (1), pp. 44-46

PY - 2012

Y1 - 2012

N2 - Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness. Copyright © 2012 Yuan-Sung Kuo et al.

AB - Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness. Copyright © 2012 Yuan-Sung Kuo et al.

KW - Centella asiatica extract

KW - opsite

KW - plant extract

KW - Plectranthus amboinicus extract

KW - unclassified drug

KW - adult

KW - aged

KW - article

KW - Centella asiatica

KW - clinical article

KW - constipation

KW - controlled study

KW - cream

KW - debridement

KW - diabetic foot

KW - dizziness

KW - drug dosage form comparison

KW - female

KW - human

KW - hydrocolloid dressing

KW - hypoglycemia

KW - insulin dependent diabetes mellitus

KW - male

KW - non insulin dependent diabetes mellitus

KW - Plectranthus

KW - Plectranthus amboinicus

KW - priority journal

KW - randomized controlled trial

KW - safety

KW - tinea pedis

KW - visual field defect

KW - wound dressing

U2 - 10.1155/2012/418679

DO - 10.1155/2012/418679

M3 - Article

VL - 2012

JO - Evidence-based Complementary and Alternative Medicine

JF - Evidence-based Complementary and Alternative Medicine

SN - 1741-427X

ER -