Platelet transfusion in thrombocytopenic cancer patients: Sometimes justified but likely insidious

Thierry Burnouf, Mohamed Elemary, Julia Radosevic, Jerard Seghatchian, Hadi Goubran

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The transfusion of platelet concentrates prepared from allogeneic single or pooled donations is a standard procedure in transfusion medicine to stop or prevent bleeding in cancer patients with thrombocytopenia undergoing surgery, chemotherapy and/or radiotherapy. While platelet transfusion may appear reasonable in many instances, greater scientific and medical attention should however be given to the possibly insidious impact of transfused platelets on the outcome of cancers. Indeed platelets and the microvesicles they release possess all the biological ingredients capable of supporting tumor growth, protecting circulating tumor cells, and to contributing to metastatic invasion. Until any randomized controlled trials can objectively document their effects on survival or cancer recurrence, minimizing the use of platelet transfusion in cancer patients appears to represent a reasonable precautionary measure.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalTransfusion and Apheresis Science
Volume56
Issue number3
DOIs
Publication statusPublished - Jun 1 2017

Keywords

  • Cancer
  • Platelet
  • Progression
  • Transfusion

ASJC Scopus subject areas

  • Hematology

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