Abstract

Platelets play a crucial role in the pathophysiological processes of hemostasis and thrombosis. Increasing evidence indicates that they fulfill much broader roles in balancing health and disease. The presence of tumor cells affects platelets both numerically, through a wide variety of mediators and cytokines, or functionally through tumor cell-induced platelet activation, the first step toward cancer-induced thrombosis. This induction results from signaling events through the different platelet receptors, or may be cytokine-mediated. Reciprocally, upon activation, the platelets will release a myriad of growth factors from their dense and α-granules and peroxisomes; these will directly impact tumor growth, tethering, and spread. A similar cross-talk is initiated between tumor microvesicles stimulating the platelets and platelet microparticles, promoting both thrombosis and tumor growth. A vicious loop of activation thereafter takes place. Platelets directly and indirectly promote tumor growth, and enable a molecular mimicry coating the malignant growth and allowing metastasizing cells to escape T-cell-mediated immunity and natural killer cell surveillance. Breaking this vicious activation loop with nonspecific platelet inhibitors, such as aspirin, or by targeting specific sites on the activation cascade may offer a mean to reduce both the risks of development and progression of cancer and the risk of thrombosis.

Original languageEnglish
Pages (from-to)296-305
Number of pages10
JournalSeminars in Thrombosis and Hemostasis
Volume40
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Blood Platelets
Neoplasms
Thrombosis
Platelet Activation
Growth
Cytokines
Molecular Mimicry
Peroxisomes
Platelet Aggregation Inhibitors
Hemostasis
Cellular Immunity
Natural Killer Cells
Aspirin
Intercellular Signaling Peptides and Proteins
T-Lymphocytes
Health

Keywords

  • antiplatelets
  • cancer
  • metastasis
  • microparticles
  • platelets
  • TCIPA

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Platelet-cancer interactions. / Goubran, Hadi A.; Stakiw, Julie; Radosevic, Mirjana; Burnouf, Thierry.

In: Seminars in Thrombosis and Hemostasis, Vol. 40, No. 3, 2014, p. 296-305.

Research output: Contribution to journalArticle

Goubran, HA, Stakiw, J, Radosevic, M & Burnouf, T 2014, 'Platelet-cancer interactions', Seminars in Thrombosis and Hemostasis, vol. 40, no. 3, pp. 296-305. https://doi.org/10.1055/s-0034-1370767
Goubran, Hadi A. ; Stakiw, Julie ; Radosevic, Mirjana ; Burnouf, Thierry. / Platelet-cancer interactions. In: Seminars in Thrombosis and Hemostasis. 2014 ; Vol. 40, No. 3. pp. 296-305.
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