Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

Paul J. Davis, Shaker A. Mousa, Geraldine P. Schechter, Hung Yun Lin

Research output: Contribution to journalReview articlepeer-review


Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalHormones and Cancer
Issue number1
Publication statusPublished - Feb 1 2020


  • 3,5,3′-Triiodo-L-thyronine (T3)
  • Degranulation
  • Integrin
  • L-Thyroxine (T4)
  • Metastasis
  • Thyroid hormone receptors
  • Tumor cell invasiveness

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cancer Research

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