Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

Paul J. Davis, Shaker A. Mousa, Geraldine P. Schechter, Hung Yun Lin

Research output: Contribution to journalReview article

Abstract

Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalHormones and Cancer
Volume11
Issue number1
DOIs
Publication statusPublished - Feb 1 2020

Keywords

  • 3,5,3′-Triiodo-L-thyronine (T3)
  • Degranulation
  • Integrin
  • L-Thyroxine (T4)
  • Metastasis
  • Thyroid hormone receptors
  • Tumor cell invasiveness

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cancer Research

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