Plastic phase-locking and magnetic mismatch response to auditory deviants in temporal lobe epilepsy

Yung Yang Lin, Fu Jung Hsiao, Yang Hsin Shih, Chun Hing Yiu, Der Jen Yen, Sheong Yeong Kwan, Tai-Tong Wong, Zin An Wu, Low Tone Ho

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The magnetic equivalent (MMNm) of mismatch negativity may reflect auditory discrimination and sensory memory. To study whether temporal lobe epilepsy (TLE) affects automatic central auditory-change processing, we recorded magnetoencephalographic (MEG) responses to standard and duration-deviant sounds in 12 TLE patients and 12 age-matched controls, and repeated MEG measurement in 8 patients 6-30 months following epilepsy surgery and in 6 controls 3-8 months after their first measurement. We compared the MMNm between patients and controls, and also evaluated intertrial phase coherences as indexed by phase-locking factors (PLF) using wavelet-based analyses. We observed longer MMNm latencies for patients than for controls. Dipole modeling and minimum-current estimates together showed bi-frontotemporal sources for MMNm. The phase locking across trials was dominant at the 4- to 14-Hz band, and the main difference in PLF between deviant- and standard-evoked responses occurred in the time frame of 150-250 ms after stimulus onset. Notably, in the 5 patients who became seizure free after removal of right temporal epileptic focus, the phase-locking phenomena resulting from deviant stimuli were enhanced, and even more distributed in the frontotemporal regions. We conclude that mesial TLE might affect auditory-change detection, and a successful surgery causes a possible plastic change in phase locking of deviant-evoked signals.

Original languageEnglish
Pages (from-to)2516-2525
Number of pages10
JournalCerebral Cortex
Volume17
Issue number11
DOIs
Publication statusPublished - Nov 1 2007
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Plastics
Wavelet Analysis
Epilepsy
Seizures

Keywords

  • Auditory MMNm
  • Magnetoencephalography
  • Neural plasticity
  • Phase-locking
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Lin, Y. Y., Hsiao, F. J., Shih, Y. H., Yiu, C. H., Yen, D. J., Kwan, S. Y., ... Ho, L. T. (2007). Plastic phase-locking and magnetic mismatch response to auditory deviants in temporal lobe epilepsy. Cerebral Cortex, 17(11), 2516-2525. https://doi.org/10.1093/cercor/bhl157

Plastic phase-locking and magnetic mismatch response to auditory deviants in temporal lobe epilepsy. / Lin, Yung Yang; Hsiao, Fu Jung; Shih, Yang Hsin; Yiu, Chun Hing; Yen, Der Jen; Kwan, Sheong Yeong; Wong, Tai-Tong; Wu, Zin An; Ho, Low Tone.

In: Cerebral Cortex, Vol. 17, No. 11, 01.11.2007, p. 2516-2525.

Research output: Contribution to journalArticle

Lin, YY, Hsiao, FJ, Shih, YH, Yiu, CH, Yen, DJ, Kwan, SY, Wong, T-T, Wu, ZA & Ho, LT 2007, 'Plastic phase-locking and magnetic mismatch response to auditory deviants in temporal lobe epilepsy', Cerebral Cortex, vol. 17, no. 11, pp. 2516-2525. https://doi.org/10.1093/cercor/bhl157
Lin, Yung Yang ; Hsiao, Fu Jung ; Shih, Yang Hsin ; Yiu, Chun Hing ; Yen, Der Jen ; Kwan, Sheong Yeong ; Wong, Tai-Tong ; Wu, Zin An ; Ho, Low Tone. / Plastic phase-locking and magnetic mismatch response to auditory deviants in temporal lobe epilepsy. In: Cerebral Cortex. 2007 ; Vol. 17, No. 11. pp. 2516-2525.
@article{74b763375b14479f8a28b7d60d823855,
title = "Plastic phase-locking and magnetic mismatch response to auditory deviants in temporal lobe epilepsy",
abstract = "The magnetic equivalent (MMNm) of mismatch negativity may reflect auditory discrimination and sensory memory. To study whether temporal lobe epilepsy (TLE) affects automatic central auditory-change processing, we recorded magnetoencephalographic (MEG) responses to standard and duration-deviant sounds in 12 TLE patients and 12 age-matched controls, and repeated MEG measurement in 8 patients 6-30 months following epilepsy surgery and in 6 controls 3-8 months after their first measurement. We compared the MMNm between patients and controls, and also evaluated intertrial phase coherences as indexed by phase-locking factors (PLF) using wavelet-based analyses. We observed longer MMNm latencies for patients than for controls. Dipole modeling and minimum-current estimates together showed bi-frontotemporal sources for MMNm. The phase locking across trials was dominant at the 4- to 14-Hz band, and the main difference in PLF between deviant- and standard-evoked responses occurred in the time frame of 150-250 ms after stimulus onset. Notably, in the 5 patients who became seizure free after removal of right temporal epileptic focus, the phase-locking phenomena resulting from deviant stimuli were enhanced, and even more distributed in the frontotemporal regions. We conclude that mesial TLE might affect auditory-change detection, and a successful surgery causes a possible plastic change in phase locking of deviant-evoked signals.",
keywords = "Auditory MMNm, Magnetoencephalography, Neural plasticity, Phase-locking, Temporal lobe epilepsy",
author = "Lin, {Yung Yang} and Hsiao, {Fu Jung} and Shih, {Yang Hsin} and Yiu, {Chun Hing} and Yen, {Der Jen} and Kwan, {Sheong Yeong} and Tai-Tong Wong and Wu, {Zin An} and Ho, {Low Tone}",
year = "2007",
month = "11",
day = "1",
doi = "10.1093/cercor/bhl157",
language = "English",
volume = "17",
pages = "2516--2525",
journal = "Cortex",
issn = "1047-3211",
publisher = "Masson SpA",
number = "11",

}

TY - JOUR

T1 - Plastic phase-locking and magnetic mismatch response to auditory deviants in temporal lobe epilepsy

AU - Lin, Yung Yang

AU - Hsiao, Fu Jung

AU - Shih, Yang Hsin

AU - Yiu, Chun Hing

AU - Yen, Der Jen

AU - Kwan, Sheong Yeong

AU - Wong, Tai-Tong

AU - Wu, Zin An

AU - Ho, Low Tone

PY - 2007/11/1

Y1 - 2007/11/1

N2 - The magnetic equivalent (MMNm) of mismatch negativity may reflect auditory discrimination and sensory memory. To study whether temporal lobe epilepsy (TLE) affects automatic central auditory-change processing, we recorded magnetoencephalographic (MEG) responses to standard and duration-deviant sounds in 12 TLE patients and 12 age-matched controls, and repeated MEG measurement in 8 patients 6-30 months following epilepsy surgery and in 6 controls 3-8 months after their first measurement. We compared the MMNm between patients and controls, and also evaluated intertrial phase coherences as indexed by phase-locking factors (PLF) using wavelet-based analyses. We observed longer MMNm latencies for patients than for controls. Dipole modeling and minimum-current estimates together showed bi-frontotemporal sources for MMNm. The phase locking across trials was dominant at the 4- to 14-Hz band, and the main difference in PLF between deviant- and standard-evoked responses occurred in the time frame of 150-250 ms after stimulus onset. Notably, in the 5 patients who became seizure free after removal of right temporal epileptic focus, the phase-locking phenomena resulting from deviant stimuli were enhanced, and even more distributed in the frontotemporal regions. We conclude that mesial TLE might affect auditory-change detection, and a successful surgery causes a possible plastic change in phase locking of deviant-evoked signals.

AB - The magnetic equivalent (MMNm) of mismatch negativity may reflect auditory discrimination and sensory memory. To study whether temporal lobe epilepsy (TLE) affects automatic central auditory-change processing, we recorded magnetoencephalographic (MEG) responses to standard and duration-deviant sounds in 12 TLE patients and 12 age-matched controls, and repeated MEG measurement in 8 patients 6-30 months following epilepsy surgery and in 6 controls 3-8 months after their first measurement. We compared the MMNm between patients and controls, and also evaluated intertrial phase coherences as indexed by phase-locking factors (PLF) using wavelet-based analyses. We observed longer MMNm latencies for patients than for controls. Dipole modeling and minimum-current estimates together showed bi-frontotemporal sources for MMNm. The phase locking across trials was dominant at the 4- to 14-Hz band, and the main difference in PLF between deviant- and standard-evoked responses occurred in the time frame of 150-250 ms after stimulus onset. Notably, in the 5 patients who became seizure free after removal of right temporal epileptic focus, the phase-locking phenomena resulting from deviant stimuli were enhanced, and even more distributed in the frontotemporal regions. We conclude that mesial TLE might affect auditory-change detection, and a successful surgery causes a possible plastic change in phase locking of deviant-evoked signals.

KW - Auditory MMNm

KW - Magnetoencephalography

KW - Neural plasticity

KW - Phase-locking

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=35148895089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35148895089&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhl157

DO - 10.1093/cercor/bhl157

M3 - Article

VL - 17

SP - 2516

EP - 2525

JO - Cortex

JF - Cortex

SN - 1047-3211

IS - 11

ER -