Abstract

The role of the hepato-protective agent plasmon-activated water (PAW) as an innovative anti-oxidant during chronic sleep deprivation (SD) is realized in this study. PAW possesses reduced hydrogen-bonded structure, higher chemical potential and significant anti-oxidative properties. In vitro tests using rat liver cell line (Clone-9) have demonstrated that PAW is non-cytotoxic and does not change the cellular migration capacity. The in vivo experiment on SD rats suffering from intense oxidative damage to the liver, an extremely common phenomenon in the present-time with deleterious effects on metabolic function, is performed by feeding PAW to replace deionized (DI) water. Experimental results indicate that PAW markedly reduces oxidative stress with enhanced bioenergetics in hepatocytes. PAW also effectively restores hepatocytic trans-membrane ion homeostasis, preserves membranous structures, and successfully improves liver function and metabolic activity. In addition, the hepato-protective effects of PAW are evidently demonstrated by the reduced values of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) and the recovery of total protein and albumin levels. With clear evidences of PAW for protecting liver from SD-induced injury, delivering PAW as a powerful hepato-protective agent should be worthy of trailblazing new clinical trials in a healthier, more natural, and more convenient way.
Original languageEnglish
Pages (from-to)9618-9626
Number of pages9
JournalRSC Advances
Volume8
Issue number18
DOIs
Publication statusPublished - 2018

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Water
Liver
Protective Agents
Rats
Sleep
Oxidative stress
Deionized water
Chemical potential
Aspartate Aminotransferases
Alanine Transaminase
Oxidants
Hydrogen
Albumins
Cells
Ions
Proteins
Membranes
Recovery
Experiments

Cite this

Plasmon-activated water effectively relieves hepatic oxidative damage resulting from chronic sleep deprivation. / Chen, Hsiao-Chien; Cheng, Chung-Yi; Chen, Li-You; Chang, Chun-Chao; Yang, Chih-Ping; Mai, Fu-Der; Liao, Wen-Chieh; Chang, Hung-Ming; Liu, Yu-Chuan.

In: RSC Advances, Vol. 8, No. 18, 2018, p. 9618-9626.

Research output: Contribution to journalArticle

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abstract = "The role of the hepato-protective agent plasmon-activated water (PAW) as an innovative anti-oxidant during chronic sleep deprivation (SD) is realized in this study. PAW possesses reduced hydrogen-bonded structure, higher chemical potential and significant anti-oxidative properties. In vitro tests using rat liver cell line (Clone-9) have demonstrated that PAW is non-cytotoxic and does not change the cellular migration capacity. The in vivo experiment on SD rats suffering from intense oxidative damage to the liver, an extremely common phenomenon in the present-time with deleterious effects on metabolic function, is performed by feeding PAW to replace deionized (DI) water. Experimental results indicate that PAW markedly reduces oxidative stress with enhanced bioenergetics in hepatocytes. PAW also effectively restores hepatocytic trans-membrane ion homeostasis, preserves membranous structures, and successfully improves liver function and metabolic activity. In addition, the hepato-protective effects of PAW are evidently demonstrated by the reduced values of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) and the recovery of total protein and albumin levels. With clear evidences of PAW for protecting liver from SD-induced injury, delivering PAW as a powerful hepato-protective agent should be worthy of trailblazing new clinical trials in a healthier, more natural, and more convenient way.",
author = "Hsiao-Chien Chen and Chung-Yi Cheng and Li-You Chen and Chun-Chao Chang and Chih-Ping Yang and Fu-Der Mai and Wen-Chieh Liao and Hung-Ming Chang and Yu-Chuan Liu",
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AU - Yang, Chih-Ping

AU - Mai, Fu-Der

AU - Liao, Wen-Chieh

AU - Chang, Hung-Ming

AU - Liu, Yu-Chuan

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