Plasma-transforming growth factor-alpha expression in residents of an arseniasis area in Taiwan

K. H. Hsu, P. Brandt-Rauf, T. M. Lin, H. Y. Chiou, C. H. Tseng, C. J. Chen, J. C J Luo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Epidemiological studies have demonstrated an association between long-term exposure to inorganic arsenic and the related adverse effects such as cancers, skin lesions, and vascular diseases. Although several hypotheses have been proposed for the mechanism of arsenic-induced pathogenesis, it remains imperfectly understood. Recent studies have suggested that alterations in growth signal transduction pathways, particularly involving transforming growth factor-alpha (TGF-alpha), may be important. Immunoassays were used to determine the plasma levels of TGF-alpha and epidermal growth factor receptor (EGFR), which is the receptor for TGF-alpha, in residents of an arseniasis area of Taiwan in relation to their estimated cumulative arsenic exposure from drinking water. No relationship between arsenic exposure and EGFR was found. However, among the high cumulative exposure group (>6 ppm-years), levels of plasma TGF-alpha (25.5±38.2 pg ml-1) and the proportion of individuals with TGF-alpha over-expression (29.4%) were significantly higher (p-1, 8.6%, respectively). There was a significant linear trend between cumulative arsenic exposure and the prevalence of plasma TGF-alpha over-expression after adjusting for age and sex (p=0.019). The results suggest that plasma TGF-alpha expression may be a useful biomarker when detecting adverse effects on arsenic exposed population.

Original languageEnglish
Pages (from-to)538-546
Number of pages9
JournalBiomarkers
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Transforming Growth Factor alpha
Arsenic
Taiwan
Plasmas
Epidermal Growth Factor Receptor
Signal transduction
Biomarkers
Skin Neoplasms
Vascular Diseases
Immunoassay
Skin Diseases
Drinking Water
Epidemiologic Studies
Signal Transduction
Skin
Association reactions
Growth
Population

ASJC Scopus subject areas

  • Biotechnology
  • Toxicology

Cite this

Hsu, K. H., Brandt-Rauf, P., Lin, T. M., Chiou, H. Y., Tseng, C. H., Chen, C. J., & Luo, J. C. J. (2006). Plasma-transforming growth factor-alpha expression in residents of an arseniasis area in Taiwan. Biomarkers, 11(6), 538-546. https://doi.org/10.1080/13547500600881488

Plasma-transforming growth factor-alpha expression in residents of an arseniasis area in Taiwan. / Hsu, K. H.; Brandt-Rauf, P.; Lin, T. M.; Chiou, H. Y.; Tseng, C. H.; Chen, C. J.; Luo, J. C J.

In: Biomarkers, Vol. 11, No. 6, 11.2006, p. 538-546.

Research output: Contribution to journalArticle

Hsu, KH, Brandt-Rauf, P, Lin, TM, Chiou, HY, Tseng, CH, Chen, CJ & Luo, JCJ 2006, 'Plasma-transforming growth factor-alpha expression in residents of an arseniasis area in Taiwan', Biomarkers, vol. 11, no. 6, pp. 538-546. https://doi.org/10.1080/13547500600881488
Hsu, K. H. ; Brandt-Rauf, P. ; Lin, T. M. ; Chiou, H. Y. ; Tseng, C. H. ; Chen, C. J. ; Luo, J. C J. / Plasma-transforming growth factor-alpha expression in residents of an arseniasis area in Taiwan. In: Biomarkers. 2006 ; Vol. 11, No. 6. pp. 538-546.
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