Plasma RANTES and eotaxin levels are correlated with the severity of chronic rhinosinusitis

Pin Zhir Chao, Chi Ming Chou, Chen Ho Chen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Eosinophilia occurs in up to 75-90% of nasal polyps in Caucasians. The chemokines eotaxin and RANTES increase eosinophil recruitment, activation, and survival, and these chemokines are significantly expressed in nasal polyps. We hypothesized that eotaxin and RANTES plasma levels might be correlated with disease severity. We compared the eotaxin and RANTES plasma levels in 20 Taiwanese patients with chronic rhinosinusitis and nasal polyps and 20 Taiwanese healthy controls. Eotaxin and RANTES plasma levels were measured by ELISA and disease severity was scored by CT scans. Compared to controls, patients with nasal polyps had significantly elevated plasma levels of eotaxin and RANTES and increased peripheral blood eosinophils (p <0.001). Eotaxin plasma levels were significantly correlated with disease severity in patients with chronic rhinosinusitis to a greater extent than were RANTES levels. RANTES and eotaxin levels were also positively correlated with the percentages of peripheral blood eosinophils. Eotaxin plasma levels are significantly correlated with disease severity in Taiwanese patients with nasal polyposis to a greater degree than are RANTES levels. Additional studies are needed to assess whether eotaxin plasma levels can be used to monitor disease progression and attenuation.

Original languageEnglish
Pages (from-to)2343-2348
Number of pages6
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume269
Issue number11
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Chronic rhinosinusitis
  • Eosinophils
  • Eotaxin
  • Nasal polyps
  • RANTES

ASJC Scopus subject areas

  • Otorhinolaryngology

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