Plasma levels in sepsis patients of annexin A1, lipoxin A4, macrophage inflammatory protein-3a, and neutrophil gelatinase-associated lipocalin

Wen Hui Tsai, Chung Hung Shih, Yuan Bin Yu, Hui Chi Hsu

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19 Citations (Scopus)

Abstract

Background: The relationship between the various cytokine responses that occur during sepsis remains controversial. Emerging evidence indicates that the proinflammatory and anti-inflammatory responses are regulated simultaneously from the beginning of sepsis. However, the roles of the novel anti-inflammatory mediators annexin (Anx)A1 and lipoxin (LX)A4 and the proinflammatory cytokines neutrophil gelatinase-associated lipocalin (NGAL) and macrophage inflammatory protein (MIP)-3a have been studied. Methods: In this study, the plasma levels of AnxA1, LXA4, NGAL, MIP-3a, interleukin (IL)-8 and IL-6 in patients with sepsis were determined on admission to the intensive care unit. The patients were classified into survivors and non-survivors based on their outcome on day 28. Results: AnxA1 and LXA4 levels were decreased in sepsis patients compared with control patients, whereas the levels of the proinflammatory cytokines MIP-3a, NGAL, IL-8, and IL-6 were elevated. Furthermore, a significantly higher level of MIP-3a was detected in nonsurviving patients compared with surviving patients ( p

Original languageEnglish
Pages (from-to)486-490
Number of pages5
JournalJournal of the Chinese Medical Association
Volume76
Issue number9
DOIs
Publication statusPublished - Sep 2013

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Keywords

  • Annexin A1
  • Lipoxin A4
  • Macrophage inflammatory protein-3a
  • Neutrophil gelatinase-associated lipocalin
  • Sepsis

ASJC Scopus subject areas

  • Medicine(all)

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