Plasma Haptoglobin Concentrations Are Elevated in Patients with Coronary Artery Disease

Chin Wei Lee, Tsai Mu Cheng, Chih Pei Lin, Ju Pin Pan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Inflammation underlies the development and progression of coronary artery plaques. Haptoglobin (Hp) is an acute phase protein, the synthesis of which is increased during inflammation. The aim of this study was to investigate plasma Hp concentrations and phenotype in patients with coronary artery disease (CAD). We recruited 359 patients with fixed luminal stenosis ≥50% in at least one coronary artery (CAD group) and 83 patients with luminal stenosis ≤40%, normal ejection fraction, and normal regional wall motion (control group). Plasma Hp concentrations were measured using a phenotype-specific enzyme-linked immunosorbent assay. Hp phenotype was determined by native polyacrylamide gel electrophoresis. Plasma lipid concentrations were measured. Plasma Hp concentrations were significantly higher in the CAD compared with the control group (262.4±144.2 vs 176.0±86.7 ng/mL, P<0.001); however, there was no between group difference in the distribution of Hp phenotype (1-1 = 7.5% vs 7.2%; 2-1 = 40.4% vs 42.2%; 2-2 = 52.1% vs 50.6%). Stepwise multivariate logistic regression revealed that high Hp concentrations (odds ratio [OR] = 5.865), male sex (OR = 3.689), hypertension (OR = 2.632), diabetes mellitus (OR = 3.300), and low-density lipoprotein concentrations (OR = 1.480) were independently associated with CAD (all P<0.05). Hp phenotype was not associated with CAD. Plasma Hp concentrations were significantly correlated with the severity of luminal stenosis (r = 0.236, P<0.001). Our findings suggest that plasma Hp concentrations may be elevated in patients with CAD. There does not appear to be any relationship between Hp phenotype and CAD. © 2013 Lee et al.

Original languageEnglish
Article numbere76817
JournalPLoS One
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 9 2013

Fingerprint

Haptoglobins
haptoglobins
Coronary Artery Disease
Plasmas
odds ratio
Phenotype
phenotype
Odds Ratio
Pathologic Constriction
coronary vessels
Coronary Vessels
coronary artery disease
inflammation
Inflammation
Native Polyacrylamide Gel Electrophoresis
Immunosorbents
Control Groups
acute phase proteins
Acute-Phase Proteins
Sex Ratio

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Plasma Haptoglobin Concentrations Are Elevated in Patients with Coronary Artery Disease. / Lee, Chin Wei; Cheng, Tsai Mu; Lin, Chih Pei; Pan, Ju Pin.

In: PLoS One, Vol. 8, No. 10, e76817, 09.10.2013.

Research output: Contribution to journalArticle

Lee, Chin Wei ; Cheng, Tsai Mu ; Lin, Chih Pei ; Pan, Ju Pin. / Plasma Haptoglobin Concentrations Are Elevated in Patients with Coronary Artery Disease. In: PLoS One. 2013 ; Vol. 8, No. 10.
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