Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility

Yung Kai Huang, Yeong Shiau Pu, Chi Jung Chung, Horng Sheng Shiue, Mo Hsiung Yang, Chien Jen Chen, Yu Mei Hsueh

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMAV, and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMAV and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.

Original languageEnglish
Pages (from-to)929-938
Number of pages10
JournalFood and Chemical Toxicology
Volume46
Issue number3
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Methylation
Arsenic
arsenic
Folic Acid
folic acid
methylation
carcinoma
Carcinoma
Plasmas
Cacodylic Acid
cacodylic acid
hydrides
Atomic absorption spectrometry
risk reduction
atomic absorption spectrometry
High performance liquid chromatography
Hydrides
Spectrum Analysis
dose response
High Pressure Liquid Chromatography

Keywords

  • Interaction
  • Plasma folate level
  • Urinary arsenic species
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility. / Huang, Yung Kai; Pu, Yeong Shiau; Chung, Chi Jung; Shiue, Horng Sheng; Yang, Mo Hsiung; Chen, Chien Jen; Hsueh, Yu Mei.

In: Food and Chemical Toxicology, Vol. 46, No. 3, 03.2008, p. 929-938.

Research output: Contribution to journalArticle

Huang, Yung Kai ; Pu, Yeong Shiau ; Chung, Chi Jung ; Shiue, Horng Sheng ; Yang, Mo Hsiung ; Chen, Chien Jen ; Hsueh, Yu Mei. / Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility. In: Food and Chemical Toxicology. 2008 ; Vol. 46, No. 3. pp. 929-938.
@article{5f58a0a694fb4a2f94160200c47595a2,
title = "Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility",
abstract = "To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMAV, and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMAV and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.",
keywords = "Interaction, Plasma folate level, Urinary arsenic species, Urothelial carcinoma",
author = "Huang, {Yung Kai} and Pu, {Yeong Shiau} and Chung, {Chi Jung} and Shiue, {Horng Sheng} and Yang, {Mo Hsiung} and Chen, {Chien Jen} and Hsueh, {Yu Mei}",
year = "2008",
month = "3",
doi = "10.1016/j.fct.2007.10.017",
language = "English",
volume = "46",
pages = "929--938",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility

AU - Huang, Yung Kai

AU - Pu, Yeong Shiau

AU - Chung, Chi Jung

AU - Shiue, Horng Sheng

AU - Yang, Mo Hsiung

AU - Chen, Chien Jen

AU - Hsueh, Yu Mei

PY - 2008/3

Y1 - 2008/3

N2 - To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMAV, and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMAV and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.

AB - To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMAV, and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMAV and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.

KW - Interaction

KW - Plasma folate level

KW - Urinary arsenic species

KW - Urothelial carcinoma

UR - http://www.scopus.com/inward/record.url?scp=38649112003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38649112003&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2007.10.017

DO - 10.1016/j.fct.2007.10.017

M3 - Article

C2 - 18054417

AN - SCOPUS:38649112003

VL - 46

SP - 929

EP - 938

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

IS - 3

ER -