Abstract

Background: Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with communityacquired pneumonia (CAP). Methods: Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients. Results: Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r = 0.554, p <0.001), CURB-65 (r = 0.510, p <0.001), and APACHE II scores (r = 0.447, p <0.001). Conclusions: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume52
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Endothelial cells
Plasma Cells
Pneumonia
Endothelial Cells
Plasmas
Molecules
Physiology
APACHE
C-Reactive Protein
Blood
Health
Anti-Bacterial Agents
Immunosorbents
Proteoglycans
Vascular Endothelium
Leukocyte Count
Assays
Intercellular Signaling Peptides and Proteins
Cells
Sepsis

Keywords

  • Biochemical marker
  • Community-acquired pneumonia
  • Endothelial cell-specific molecule-1
  • Pneumonia severity index

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia. / Kao, Shang Jyh; Chuang, Chun Yi; Tang, Chih Hsin; Lin, Chien Huang; Bien, Mauo Ying; Yu, Ming Chih; Bai, Kuan Jen; Yang, Shun Fa; Chien, Ming Hsien.

In: Clinical Chemistry and Laboratory Medicine, Vol. 52, No. 3, 2014, p. 445-451.

Research output: Contribution to journalArticle

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title = "Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia",
abstract = "Background: Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with communityacquired pneumonia (CAP). Methods: Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients. Results: Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r = 0.554, p <0.001), CURB-65 (r = 0.510, p <0.001), and APACHE II scores (r = 0.447, p <0.001). Conclusions: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.",
keywords = "Biochemical marker, Community-acquired pneumonia, Endothelial cell-specific molecule-1, Pneumonia severity index",
author = "Kao, {Shang Jyh} and Chuang, {Chun Yi} and Tang, {Chih Hsin} and Lin, {Chien Huang} and Bien, {Mauo Ying} and Yu, {Ming Chih} and Bai, {Kuan Jen} and Yang, {Shun Fa} and Chien, {Ming Hsien}",
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T1 - Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia

AU - Kao, Shang Jyh

AU - Chuang, Chun Yi

AU - Tang, Chih Hsin

AU - Lin, Chien Huang

AU - Bien, Mauo Ying

AU - Yu, Ming Chih

AU - Bai, Kuan Jen

AU - Yang, Shun Fa

AU - Chien, Ming Hsien

PY - 2014

Y1 - 2014

N2 - Background: Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with communityacquired pneumonia (CAP). Methods: Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients. Results: Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r = 0.554, p <0.001), CURB-65 (r = 0.510, p <0.001), and APACHE II scores (r = 0.447, p <0.001). Conclusions: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.

AB - Background: Endothelial cell-specific molecule (ESM)-1 is a soluble proteoglycan expressed by the vascular endothelium and which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels are found in immunocompetent patients with sepsis. The aim of this study was to investigate differential changes in plasma levels of ESM-1 before and after antibiotic treatment in hospitalized adult patients with communityacquired pneumonia (CAP). Methods: Plasma ESM-1 levels were measured in 82 adult patients with CAP and 82 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II), CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in these patients. Results: Results showed a decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the concentrations of C-reactive protein (CRP) and ESM-1 after antibiotic treatment. The plasma concentration of ESM-1, but not CRP or the WBC count, was correlated with the severity of CAP based on the PSI (r = 0.554, p <0.001), CURB-65 (r = 0.510, p <0.001), and APACHE II scores (r = 0.447, p <0.001). Conclusions: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.

KW - Biochemical marker

KW - Community-acquired pneumonia

KW - Endothelial cell-specific molecule-1

KW - Pneumonia severity index

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SN - 1434-6621

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