Plasma apelin: A novel biomarker for predicting diabetes

Wen Ya Ma, Tse Ya Yu, Jung Nan Wei, Chi Sheng Hung, Mao Shin Lin, Ying Jhu Liao, Dee Pei, Ching Chieh Su, Kuo Cheng Lu, Pi Hua Liu, Cheng Hsin Lin, Lee Ming Chuang, Hsien Li Kao, Jou Wei Lin, Ya Ju Chuang, Hung Yuan Li

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Apelin regulates insulin sensitivity and secretion in animals. However, whether plasma apelin predicts incident diabetes in humans remains unknown. Methods: We studied a cohort including 447 subjects (148 men, 299 women) without diabetes and followed for an average of 3. y. Diabetes was diagnosed by an oral glucose tolerance test, plasma hemoglobin A1c, and if the subject was taking medications for diabetes. Plasma apelin-12 at baseline was measured with a commercial kit. Results: Plasma apelin concentrations were higher in women than in men at baseline (p= 0.007). During follow-up, 43 subjects developed type 2 diabetes. Higher plasma apelin concentrations were associated with a higher risk of diabetes in men (p= 0.049) but not in women. Plasma apelin predicted incident type 2 diabetes in men (hazard ratio, 2.13, 95% CI 1.29-3.51, p

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalClinica Chimica Acta
Volume435
DOIs
Publication statusPublished - Aug 5 2014
Externally publishedYes

Fingerprint

Biomarkers
Medical problems
Plasmas
Type 2 Diabetes Mellitus
Glucose Tolerance Test
Insulin Resistance
Hemoglobins
Hazards
Animals
Insulin
Glucose

Keywords

  • Apelin
  • Biomarker
  • Diabetes
  • Predict

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ma, W. Y., Yu, T. Y., Wei, J. N., Hung, C. S., Lin, M. S., Liao, Y. J., ... Li, H. Y. (2014). Plasma apelin: A novel biomarker for predicting diabetes. Clinica Chimica Acta, 435, 18-23. https://doi.org/10.1016/j.cca.2014.03.030

Plasma apelin : A novel biomarker for predicting diabetes. / Ma, Wen Ya; Yu, Tse Ya; Wei, Jung Nan; Hung, Chi Sheng; Lin, Mao Shin; Liao, Ying Jhu; Pei, Dee; Su, Ching Chieh; Lu, Kuo Cheng; Liu, Pi Hua; Lin, Cheng Hsin; Chuang, Lee Ming; Kao, Hsien Li; Lin, Jou Wei; Chuang, Ya Ju; Li, Hung Yuan.

In: Clinica Chimica Acta, Vol. 435, 05.08.2014, p. 18-23.

Research output: Contribution to journalArticle

Ma, WY, Yu, TY, Wei, JN, Hung, CS, Lin, MS, Liao, YJ, Pei, D, Su, CC, Lu, KC, Liu, PH, Lin, CH, Chuang, LM, Kao, HL, Lin, JW, Chuang, YJ & Li, HY 2014, 'Plasma apelin: A novel biomarker for predicting diabetes', Clinica Chimica Acta, vol. 435, pp. 18-23. https://doi.org/10.1016/j.cca.2014.03.030
Ma WY, Yu TY, Wei JN, Hung CS, Lin MS, Liao YJ et al. Plasma apelin: A novel biomarker for predicting diabetes. Clinica Chimica Acta. 2014 Aug 5;435:18-23. https://doi.org/10.1016/j.cca.2014.03.030
Ma, Wen Ya ; Yu, Tse Ya ; Wei, Jung Nan ; Hung, Chi Sheng ; Lin, Mao Shin ; Liao, Ying Jhu ; Pei, Dee ; Su, Ching Chieh ; Lu, Kuo Cheng ; Liu, Pi Hua ; Lin, Cheng Hsin ; Chuang, Lee Ming ; Kao, Hsien Li ; Lin, Jou Wei ; Chuang, Ya Ju ; Li, Hung Yuan. / Plasma apelin : A novel biomarker for predicting diabetes. In: Clinica Chimica Acta. 2014 ; Vol. 435. pp. 18-23.
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