Abstract
Adverse cutaneous drug reactions (ACDRs) are common in clinical practice and occur in about 5% of antipsychotic-treated patients. Most ACDRs are benign, but a small percentage of them are serious and life threatening. Pityriasis rosea (PR)-like eruption is a common cutaneous adverse reaction related to many drugs. Clozapine, a complex neurotransmitter receptor-binding in antipsychotic agent, is usually used for treatment-resistant schizophrenia. Clozapine-related ACDRs have been reported frequently, but clozapine-induced PR-like eruption has been reported once in the literature. We report a 54-year-old male patient with chronic schizophrenia who had received clozapine for 28 days and developed generalized skin rashes, high fever, and elevated values in liver function tests. His clozapine was immediately discontinued. He received acute managements with steroid and antihistamine, and his symptoms were relieved after treatment. This case report can be used to remind clinicians of keeping in mind the potential of clozapine-associated ACDRs.
| Original language | English |
|---|---|
| Journal | General Hospital Psychiatry |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 2012 |
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Keywords
- Adverse cutaneous drug reactions
- Clozapine
- Pityriasis rosea
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Pityriasis Rosea-like eruption associated with Clozapine : A case report. / Lai, Ya Wen; Chou, Che Yi; Shen, Winston W.; Lu, Mong Liang.
In: General Hospital Psychiatry, Vol. 34, No. 6, 11.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pityriasis Rosea-like eruption associated with Clozapine
T2 - A case report
AU - Lai, Ya Wen
AU - Chou, Che Yi
AU - Shen, Winston W.
AU - Lu, Mong Liang
PY - 2012/11
Y1 - 2012/11
N2 - Adverse cutaneous drug reactions (ACDRs) are common in clinical practice and occur in about 5% of antipsychotic-treated patients. Most ACDRs are benign, but a small percentage of them are serious and life threatening. Pityriasis rosea (PR)-like eruption is a common cutaneous adverse reaction related to many drugs. Clozapine, a complex neurotransmitter receptor-binding in antipsychotic agent, is usually used for treatment-resistant schizophrenia. Clozapine-related ACDRs have been reported frequently, but clozapine-induced PR-like eruption has been reported once in the literature. We report a 54-year-old male patient with chronic schizophrenia who had received clozapine for 28 days and developed generalized skin rashes, high fever, and elevated values in liver function tests. His clozapine was immediately discontinued. He received acute managements with steroid and antihistamine, and his symptoms were relieved after treatment. This case report can be used to remind clinicians of keeping in mind the potential of clozapine-associated ACDRs.
AB - Adverse cutaneous drug reactions (ACDRs) are common in clinical practice and occur in about 5% of antipsychotic-treated patients. Most ACDRs are benign, but a small percentage of them are serious and life threatening. Pityriasis rosea (PR)-like eruption is a common cutaneous adverse reaction related to many drugs. Clozapine, a complex neurotransmitter receptor-binding in antipsychotic agent, is usually used for treatment-resistant schizophrenia. Clozapine-related ACDRs have been reported frequently, but clozapine-induced PR-like eruption has been reported once in the literature. We report a 54-year-old male patient with chronic schizophrenia who had received clozapine for 28 days and developed generalized skin rashes, high fever, and elevated values in liver function tests. His clozapine was immediately discontinued. He received acute managements with steroid and antihistamine, and his symptoms were relieved after treatment. This case report can be used to remind clinicians of keeping in mind the potential of clozapine-associated ACDRs.
KW - Adverse cutaneous drug reactions
KW - Clozapine
KW - Pityriasis rosea
UR - http://www.scopus.com/inward/record.url?scp=84867845390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867845390&partnerID=8YFLogxK
U2 - 10.1016/j.genhosppsych.2012.03.002
DO - 10.1016/j.genhosppsych.2012.03.002
M3 - Article
C2 - 22516218
AN - SCOPUS:84867845390
VL - 34
JO - General Hospital Psychiatry
JF - General Hospital Psychiatry
SN - 0163-8343
IS - 6
ER -