Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice

Chi Chang Huang, Yu Tang Tung, Kai Chung Cheng, Jyh Horng Wu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.

Original languageEnglish
Pages (from-to)726-731
Number of pages6
JournalFood Chemistry
Volume125
Issue number2
DOIs
Publication statusPublished - Mar 15 2011
Externally publishedYes

Fingerprint

carbon tetrachloride
Carbon Tetrachloride
Vitis
Liver
Silymarin
grapes
liver
stems
Macrophages
Bioelectric potentials
resveratrol
mice
Wounds and Injuries
Transaminases
Bioactivity
Medicine
Lipopolysaccharides
Assays
Anti-Inflammatory Agents
viniferins

Keywords

  • Hepatoprotection
  • Resveratrol derivatives
  • Stem
  • Vitis kelungensis
  • Wild grape

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

Cite this

Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice. / Huang, Chi Chang; Tung, Yu Tang; Cheng, Kai Chung; Wu, Jyh Horng.

In: Food Chemistry, Vol. 125, No. 2, 15.03.2011, p. 726-731.

Research output: Contribution to journalArticle

Huang, Chi Chang ; Tung, Yu Tang ; Cheng, Kai Chung ; Wu, Jyh Horng. / Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice. In: Food Chemistry. 2011 ; Vol. 125, No. 2. pp. 726-731.
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