Physiological and pathophysiological regulation of cytochrome P450

Edward T. Morgan, Marion B. Sewer, Heinrich Iber, Frank J. Gonzalez, Ying Hue Lee, Robert H. Tukey, Steve Okino, Tien Vu, Yue Hwa Chen, Jaspreet S. Sidhu, Curtis J. Omiecinski

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology '98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.

Original languageEnglish
Pages (from-to)1232-1240
Number of pages9
JournalDrug Metabolism and Disposition
Volume26
Issue number12
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Gene Knockout Techniques
San Francisco
Reporter Genes
Knockout Mice
Cytochrome P-450 Enzyme System
Fluorescent Antibody Technique
Hepatocytes
Genes
Hormones
Cytokines
Gene Expression
Cell Line
Cell culture
Gene expression
Cells
Imaging techniques

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Morgan, E. T., Sewer, M. B., Iber, H., Gonzalez, F. J., Lee, Y. H., Tukey, R. H., ... Omiecinski, C. J. (1998). Physiological and pathophysiological regulation of cytochrome P450. Drug Metabolism and Disposition, 26(12), 1232-1240.

Physiological and pathophysiological regulation of cytochrome P450. / Morgan, Edward T.; Sewer, Marion B.; Iber, Heinrich; Gonzalez, Frank J.; Lee, Ying Hue; Tukey, Robert H.; Okino, Steve; Vu, Tien; Chen, Yue Hwa; Sidhu, Jaspreet S.; Omiecinski, Curtis J.

In: Drug Metabolism and Disposition, Vol. 26, No. 12, 1998, p. 1232-1240.

Research output: Contribution to journalArticle

Morgan, ET, Sewer, MB, Iber, H, Gonzalez, FJ, Lee, YH, Tukey, RH, Okino, S, Vu, T, Chen, YH, Sidhu, JS & Omiecinski, CJ 1998, 'Physiological and pathophysiological regulation of cytochrome P450', Drug Metabolism and Disposition, vol. 26, no. 12, pp. 1232-1240.
Morgan ET, Sewer MB, Iber H, Gonzalez FJ, Lee YH, Tukey RH et al. Physiological and pathophysiological regulation of cytochrome P450. Drug Metabolism and Disposition. 1998;26(12):1232-1240.
Morgan, Edward T. ; Sewer, Marion B. ; Iber, Heinrich ; Gonzalez, Frank J. ; Lee, Ying Hue ; Tukey, Robert H. ; Okino, Steve ; Vu, Tien ; Chen, Yue Hwa ; Sidhu, Jaspreet S. ; Omiecinski, Curtis J. / Physiological and pathophysiological regulation of cytochrome P450. In: Drug Metabolism and Disposition. 1998 ; Vol. 26, No. 12. pp. 1232-1240.
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