Physiological and pathophysiological regulation of cytochrome P450

Edward T. Morgan, Marion B. Sewer, Heinrich Iber, Frank J. Gonzalez, Ying Hue Lee, Robert H. Tukey, Steve Okino, Tien Vu, Yue Hwa Chen, Jaspreet S. Sidhu, Curtis J. Omiecinski

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology '98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.

Original languageEnglish
Pages (from-to)1232-1240
Number of pages9
JournalDrug Metabolism and Disposition
Issue number12
Publication statusPublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology


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