Physical characterization and drug release profiling for hard capsules prepared with hydroxypropylcellulose or polyethylene oxide

Chien Yuan Lee, Gan Lin Chen, Ming Thau Sheu, Cheng Hsiung Liu

Research output: Contribution to journalArticle

Abstract

In this study, hard capsule shells were made by a heat-melting method, which involved heating Polyethylene oxide (PEO, MW 200000) or hydroxypropyl cellulose (HPC, MW 80,000,100,000 and 370000) powder in a mold, followed by inserting a suitable size of pestle in a mold to coat the melted shell materials (HPC or PEO) onto pestle with a certain force. The more satisfactory were prepared at the temperature higher than melting point of corresponding polymer. The water uptake and dissolution test of various capsule shells were evaluated in acidic or basic buffer with added inorganic salt including sodium chloride, potassium chloride, calcium chloride and aluminum chloride. Propranolol hydrochloride and theophylline were selected as the model drugs. Propranolol hydrochloride released from various capsules was faster than that of theophylline due to the higher solubility of the former. There were no significantly different in the release rate in the formulation containing either macrocrystalline cellulose (MCC, Avicel®) or lactose as diluents. Moreover, Release rate was decreased with increasing viscosity grades of HPC used as shell materials. Inorganic salt shows marked influence on the dissolution rate and the rate decreased with increasing concentration of salt in dissolution medium. The drug release from HPC capsules was greater affected by electrolytes than that from gelatin and PEO capsules.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalChinese Pharmaceutical Journal
Volume58
Issue number2-6
Publication statusPublished - Apr 2006

Keywords

  • Dissolution
  • Electrolyte effects
  • Hard capsules
  • Hydroxypropyl cellulose
  • Polyethylene oxide

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Bioengineering

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