Physical and biological evaluation of low-molecular-weight hyaluronic Acid/Fe3O4 nanoparticle for targeting MCF7 breast cancer cells

Hsin Ta Wang, Po Chien Chou, Ping Han Wu, Chi Ming Lee, Kang Hsin Fan, Wei Jen Chang, Sheng Yang Lee, Haw Ming Huang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Low-molecular-weight hyaluronic acid (LMWHA) was integrated with superparamagnetic Fe3O4 nanoparticles (Fe3O4 NPs). The size distribution, zeta potential, viscosity, thermogravimetric and paramagnetic properties of the LMWHA-Fe3O4 NPs were systematically examined. For cellular experiments, MCF7 breast cancer cell line was carried out. In addition, the cell targeting ability and characteristics of the LMWHA-Fe3O4 NPs for MCF7 breast cancer cells were analyzed using the thiocyanate method and time-of-flight secondary ion mass spectrometry (TOF-SIMS). The experimental results showed that the LMWHA-Fe3O4 NPs were not only easily injectable due to their low viscosity, but also exhibited a significant superparamagnetic property. Furthermore, the in vitro assay results showed that the NPs had negligible cytotoxicity and exhibited a good cancer cell targeting ability. Overall, the results therefore suggest that the LMWHA-Fe3O4 NPs have considerable potential as an injectable agent for enhanced magnetic resonance imaging (MRI) and/or hyperthermia treatment in breast cancer therapy.

Original languageEnglish
Article number1094
Issue number5
Publication statusPublished - May 11 2020


  • Hyaluronic acid
  • Iron oxide
  • Low molecular weight
  • Nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics


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