Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils

Tsung Hsien Chou, Ih Sheng Chen, Tsong Long Hwang, Tai Chi Wang, Zong-Huei Li, Lin Yang Cheng, Ya Chih Chang, Jui Ying Cho, Jih Jung Chen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Six new phthalides, (S)-3-ethyl-7-hydroxy-6-methoxyphthalide (1), (S)-3-ethyl-7-hydroxy-5,6-dimethoxyphthalide (2), (S)-3-ethyl-5,6,7- trimethoxyphfhalide (3), (R)-3-ethyl-7-hydroxy-6-methoxyphthalide (4), (Z)-3-ethylidene-7-hydroxy-6-methoxyphthalide (5), and (Z)-3-ethylidene-6,7- dimethoxyphthalide (6), have been isolated from the root of Pittosporum illicioides var. illicioides, together with seven known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1-4 exhibited inhibition (IC50 ≤ 29.8 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5 and 6 inhibited fMLP/CB-induced elastase release with IC50 values of 38.6 ± 4.3 and 33.9 ± 3.9 μM, respectively.

Original languageEnglish
Pages (from-to)1692-1695
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number10
DOIs
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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    Chou, T. H., Chen, I. S., Hwang, T. L., Wang, T. C., Li, Z-H., Cheng, L. Y., Chang, Y. C., Cho, J. Y., & Chen, J. J. (2008). Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils. Journal of Natural Products, 71(10), 1692-1695. https://doi.org/10.1021/np8004503