Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ

Chun Wen Hsiao, Er Yuan Chuang, Hsin Lung Chen, Dehui Wan, Chiranjeevi Korupalli, Zi Xian Liao, Ya Ling Chiu, Wei Tso Chia, Kun Ju Lin, Hsing Wen Sung

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Repeated cancer treatments are common, owing to the aggressive and resistant nature of tumors. This work presents a chitosan (CS) derivative that contains self-doped polyaniline (PANI) side chains, capable of self-assembling to form micelles and then transforming into hydrogels driven by a local change in pH. Analysis results of small-angle X-ray scattering indicate that the sol-gel transition of this CS derivative may provide the mechanical integrity to maintain its spatial stability in the microenvironment of solid tumors. The micelles formed in the CS hydrogel function as nanoscaled heating sources upon exposure to near-infrared light, thereby enabling the selective killing of cancer cells in a light-treated area. Additionally, photothermal efficacy of the micellar hydrogel is evaluated using a tumor-bearing mouse model; hollow gold nanospheres (HGNs) are used for comparison. Given the ability of the micellar hydrogel to provide spatial stability within a solid tumor, which prevents its leakage from the injection site, the therapeutic efficacy of this hydrogel, as a photothermal therapeutic agent for repeated treatments, exceeds that of nanosized HGNs. Results of this study demonstrate that this in situ-formed micellar hydrogel is a highly promising modality for repeated cancer treatments, providing a clinically viable, minimally invasive phototherapeutic option for therapeutic treatment.

Original languageEnglish
Pages (from-to)26-35
Number of pages10
JournalBiomaterials
Volume56
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Fingerprint

Hydrogels
Hydrogel
Ablation
Tumors
Chitosan
Oncology
Nanospheres
Micelles
Neoplasms
Gold
Bearings (structural)
Derivatives
Therapeutics
X ray scattering
Light
Sol-gels
Light sources
Polyaniline
Tumor Microenvironment
Polymethyl Methacrylate

Keywords

  • Cancer therapy
  • Multiple treatment sessions
  • PH-responsive micellar hydrogel
  • Photothermal agent
  • Self-doped conducting polymer

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ. / Hsiao, Chun Wen; Chuang, Er Yuan; Chen, Hsin Lung; Wan, Dehui; Korupalli, Chiranjeevi; Liao, Zi Xian; Chiu, Ya Ling; Chia, Wei Tso; Lin, Kun Ju; Sung, Hsing Wen.

In: Biomaterials, Vol. 56, 01.01.2015, p. 26-35.

Research output: Contribution to journalArticle

Hsiao, Chun Wen ; Chuang, Er Yuan ; Chen, Hsin Lung ; Wan, Dehui ; Korupalli, Chiranjeevi ; Liao, Zi Xian ; Chiu, Ya Ling ; Chia, Wei Tso ; Lin, Kun Ju ; Sung, Hsing Wen. / Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ. In: Biomaterials. 2015 ; Vol. 56. pp. 26-35.
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