Photoproducts of naproxen in alcoholic solvents

Hsin Tsung Ho, An Bang Wu, Pen Yuan Lin, Jen Ai Lee, Pen Yueh Hung

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A sample of 5 mM naproxen in methanol or ethanol was photoirradiated with a Hanovia 200 W high-pressure quartz Hg lamp. In total, 6 photoproducts derived from each sample were observed from the HPLC chromatograms. Four major photoproducts were separated, and their structures elucidated by EI-MS and various spectroscopic methods. A reaction scheme of naproxen in alcoholic solvents is proposed: the photochemical reaction routes occur mainly via decarboxylation and esterification, followed by oxidation with singlet oxygen to produce an alcohol and a ketone.

Original languageEnglish
Title of host publicationBiomedical Chromatography
PublisherNova Science Publishers, Inc.
Pages159-170
Number of pages12
ISBN (Electronic)9781616684709
ISBN (Print)9781607412915
Publication statusPublished - Jan 1 2010

Fingerprint

Naproxen
alcohol abuse
photochemical reactions
Singlet Oxygen
Decarboxylation
Quartz
singlet oxygen
decarboxylation
Esterification
Photochemical reactions
esterification
quartz
ketones
Ketones
Electric lamps
Methanol
methanol
Ethanol
alcohols
High Pressure Liquid Chromatography

Keywords

  • EI-MS
  • HPLC
  • Naproxen
  • Photochemistry

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ho, H. T., Wu, A. B., Lin, P. Y., Lee, J. A., & Hung, P. Y. (2010). Photoproducts of naproxen in alcoholic solvents. In Biomedical Chromatography (pp. 159-170). Nova Science Publishers, Inc..

Photoproducts of naproxen in alcoholic solvents. / Ho, Hsin Tsung; Wu, An Bang; Lin, Pen Yuan; Lee, Jen Ai; Hung, Pen Yueh.

Biomedical Chromatography. Nova Science Publishers, Inc., 2010. p. 159-170.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ho, HT, Wu, AB, Lin, PY, Lee, JA & Hung, PY 2010, Photoproducts of naproxen in alcoholic solvents. in Biomedical Chromatography. Nova Science Publishers, Inc., pp. 159-170.
Ho HT, Wu AB, Lin PY, Lee JA, Hung PY. Photoproducts of naproxen in alcoholic solvents. In Biomedical Chromatography. Nova Science Publishers, Inc. 2010. p. 159-170
Ho, Hsin Tsung ; Wu, An Bang ; Lin, Pen Yuan ; Lee, Jen Ai ; Hung, Pen Yueh. / Photoproducts of naproxen in alcoholic solvents. Biomedical Chromatography. Nova Science Publishers, Inc., 2010. pp. 159-170
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