Photoproducts of indomethacin

Pen Yuan Lin, Fu An Chen, An Bang Wu, Su Hui Chao, Yu Tang Peng, Vickie M H Lee, Chau Yang Chen

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1 Citation (Scopus)


In a photochemical chamber, a sample of 27.9 mM indomethacin (IN) in methanol was exposed to a Philips 400-W UV lamp for 5 days in normal atmosphere. Four photoproducts were separated using high-performance liquid chromatography, and their structures were elucidated by various spectroscopic methods, including liquid chromatography–electrospray ionization–mass spectrometry. A reaction scheme of IN in methanol is proposed: The photochemical reaction routes occur mainly via esterification and decarboxylation, followed by oxidation with singlet oxygen to produce an aldehyde. A β-hydroxy-γ-lactone was also formed through a photochemical [2 + 2] cycloaddition, and its structure was confirmed by single-crystal X-ray diffraction.

Original languageEnglish
Pages (from-to)1777-1783
Number of pages7
JournalJournal of the Iranian Chemical Society
Issue number10
Publication statusPublished - Oct 1 2016


  • Indomethacin
  • Photoproduct
  • β-Hydroxy-γ-lactone

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Lin, P. Y., Chen, F. A., Wu, A. B., Chao, S. H., Peng, Y. T., Lee, V. M. H., & Chen, C. Y. (2016). Photoproducts of indomethacin. Journal of the Iranian Chemical Society, 13(10), 1777-1783.