Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion

Chuan Hang Yu, Hsin Ming Chen, Hsien Yen Hung, Shih Jung Cheng, Tsuimin Tsai, Chun Pin Chiang

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Our previous studies showed that oral verrucous hyperplasia (OVH) lesions can be successfully treated with a topical 5-aminolevulinic acid-mediated photodynamic therapy (topical ALA-PDT) protocol using a 635-nm light-emitting diode light source. In this study, we report the clinical outcomes of 36 OVH lesions treated by this protocol and assess what clinicopathological parameters of OVH lesions could influence PDT treatment outcomes. We found that all the 36 OVH lesions showed complete response (CR) after an average of 3.8 (range, 1-6) treatments of topical ALA-PDT. OVH lesions with an clinical appearance of a mass, with the greatest diameter 40 μm (p = 0.003), respectively. Multivariate analysis showed that only the clinical appearance of OVH lesions was the independent factor (p = 0.0069). We conclude that complete regression of OVH lesions can be achieved by less than seven treatments of topical ALA-PDT once a week. The PDT treatment outcome for OVH depends on the outer appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalOral Oncology
Volume44
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • 5-Aminolevulinic acid
  • Oral verrucous hyperplasia
  • Topical photodynamic therapy

ASJC Scopus subject areas

  • Oncology

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