Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®

C. J. Chang, Y. L. Lai, C. J. Wong

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented neoplasms of the skin, respiratory, gastrointestinal and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using Photofrin® in the treatment of squamous cell carcinomas of feline facial skin. Materials and Methods: Cats with naturally occurring squamous cell carcinomas of the skin were entered into the study. PDT was delivered to the tumors using an argon-pumped dye laser 48 hours after the administration of the photosensitizer porfimer sodium (Photofrin®). Following treatment, the tumors were evaluated for complete response rates and local control durations. Results: Eight tumors were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p < 0.0001). Complete response was achieved in 100% of the T1a tumors and 53% of the T1b tumors; the overall 1-year local control rate for all treated tumors was 62%. Clinical, hematological, and biochemical evidence of toxicity was not seen in any cat following drug administration. Conclusion: PDT with the photosensitizer Photofrin® was safe and effective in treating early stage squamous cell carcinomas of the feline skin.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalChang Gung Medical Journal
Volume21
Issue number1
Publication statusPublished - Jan 1 1998
Externally publishedYes

Fingerprint

Dihematoporphyrin Ether
Photochemotherapy
Squamous Cell Carcinoma
Cats
Neoplasms
Photosensitizing Agents
Felidae
Skin
Urogenital System
Dye Lasers
Argon
Skin Neoplasms
Respiratory System
Therapeutics
Safety
Pharmaceutical Preparations

Keywords

  • Photodynamic therapy
  • Photofrin®
  • Photosensitizer
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®. / Chang, C. J.; Lai, Y. L.; Wong, C. J.

In: Chang Gung Medical Journal, Vol. 21, No. 1, 01.01.1998, p. 13-19.

Research output: Contribution to journalArticle

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abstract = "Background: Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented neoplasms of the skin, respiratory, gastrointestinal and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using Photofrin{\circledR} in the treatment of squamous cell carcinomas of feline facial skin. Materials and Methods: Cats with naturally occurring squamous cell carcinomas of the skin were entered into the study. PDT was delivered to the tumors using an argon-pumped dye laser 48 hours after the administration of the photosensitizer porfimer sodium (Photofrin{\circledR}). Following treatment, the tumors were evaluated for complete response rates and local control durations. Results: Eight tumors were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p < 0.0001). Complete response was achieved in 100{\%} of the T1a tumors and 53{\%} of the T1b tumors; the overall 1-year local control rate for all treated tumors was 62{\%}. Clinical, hematological, and biochemical evidence of toxicity was not seen in any cat following drug administration. Conclusion: PDT with the photosensitizer Photofrin{\circledR} was safe and effective in treating early stage squamous cell carcinomas of the feline skin.",
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