Phosphorylation-dependent SUMOylation of the transcription factor NF-E2

Yee Fun Su, Yu Chiau Shyu, Che Kun James Shen, Jaulang Hwang

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5 Citations (Scopus)

Abstract

Nuclear factor erythroid-derived 2 (NF-E2), a heterodimer composed of p45 and p18, is a transcriptional activator in hematopoietic progenitors. The transcriptional activity of NF-E2 is not only upregulated by SUMOylation but also stimulated by the cAMP-dependent protein kinase A (PKA). However, the relationship between SUMOylation and phosphorylation in the activation of NF-E2 is unclear. In the present studies, we have demonstrated that PKA enhances NF-E2 SUMOylation in an in vitro system using purified proteins, suggesting a possible mechanism for PKA-dependent activation of the NF-E2 transcription factor through SUMOylation.

Original languageEnglish
Article numbere44608
JournalPLoS One
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 10 2012

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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