Phosphorylation-dependent SUMOylation of the transcription factor NF-E2

Yee Fun Su, Yu Chiau Shyu, Che Kun James Shen, Jaulang Hwang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Nuclear factor erythroid-derived 2 (NF-E2), a heterodimer composed of p45 and p18, is a transcriptional activator in hematopoietic progenitors. The transcriptional activity of NF-E2 is not only upregulated by SUMOylation but also stimulated by the cAMP-dependent protein kinase A (PKA). However, the relationship between SUMOylation and phosphorylation in the activation of NF-E2 is unclear. In the present studies, we have demonstrated that PKA enhances NF-E2 SUMOylation in an in vitro system using purified proteins, suggesting a possible mechanism for PKA-dependent activation of the NF-E2 transcription factor through SUMOylation.

Original languageEnglish
Article numbere44608
JournalPLoS One
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 10 2012

Fingerprint

NF-E2 Transcription Factor
Sumoylation
Phosphorylation
cAMP-dependent protein kinase
Cyclic AMP-Dependent Protein Kinases
phosphorylation
Transcription Factors
transcription factors
Chemical activation
Proteins
proteins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Phosphorylation-dependent SUMOylation of the transcription factor NF-E2. / Su, Yee Fun; Shyu, Yu Chiau; Shen, Che Kun James; Hwang, Jaulang.

In: PLoS One, Vol. 7, No. 9, e44608, 10.09.2012.

Research output: Contribution to journalArticle

Su, Yee Fun ; Shyu, Yu Chiau ; Shen, Che Kun James ; Hwang, Jaulang. / Phosphorylation-dependent SUMOylation of the transcription factor NF-E2. In: PLoS One. 2012 ; Vol. 7, No. 9.
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