PHILADELPHIA-CHROMOSOME-POSITIVE PRELEUKÆMIC STATE

George P. Canellos, Jacqueline Whang-Peng

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Serial chromosomal analyses were performed in an untreated patient who demonstrated little or no hæmatological disease for over 5 years before the development of overt blastic leukæmia. The Philadelphia chromosome (Ph') was present in a small percentage of marrow cells during the preleukæmic period. Hæmatological remission of the blastic leukæmia was achieved with hæmopoiesis derived from a Ph' positive cell line. The Ph' chromosome was an indicator of the preleukæmic state in the absence of other abnormalities.

Original languageEnglish
Pages (from-to)1227-1229
Number of pages3
JournalThe Lancet
Volume300
Issue number7789
DOIs
Publication statusPublished - Dec 9 1972
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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