Phase transformation on bone cement: Monocalcium phosphate monohydrate into calcium-deficient hydroxyapatite during setting

Shyuan Yow Chen, Shih Fu Ou, Nai Cia Teng, Chun Ming Kung, Hsien Lung Tsai, Kuo Tien Chu, Keng Liang Ou

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study evaluated the phase transformation of calcium phosphate cement (CPC) using a mixture of monocalcium phosphate monohydrate (MCPM) and CaCO 3 as the solid phase and either water or a sodium phosphate buffer (SPB) solution (pH=7.0) as the liquid phase. The synthetic CPC was characterized by X-ray diffraction (XRD) analysis and transmission electron microscopy (TEM). The setting reaction in the SPB solution involved three phase transformations. Firstly, MCPM and CaCO3 reacted with sodium phosphate immediately to form dicalcium phosphate dehydrate (DCPD) which continued to dissolve. Secondly, meanwhile, an intermediate amorphous calcium phosphate (ACP) was formed. Finally, ACP transformed into calcium-deficient hydroxyapatite (CDHA). In contrast, the reaction stopped at the first stage in water. Consequently, the SPB solution not only caused the dissolution of DCPD but also provided the buffering capacity to induce the conversion of the starting materials to CDHA.

Original languageEnglish
Pages (from-to)2451-2455
Number of pages5
JournalCeramics International
Volume39
Issue number3
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Calcium phosphate cement
  • Monocalcium phosphate monohydrate
  • Phase transformation
  • Setting reaction

ASJC Scopus subject areas

  • Ceramics and Composites
  • Process Chemistry and Technology
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry

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