Phase II randomized study of weekly docetaxel alone or plus UFUR treatment in non-small cell lung cancer patients who failed previous chemotherapy

Kun Ta Chou, Yuh Min Chen, Jen Fu Shih, Reury Perng Perng, Chun Ming Tsai, Jacqueline Whang-Peng

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: This study aimed to assess the feasibility and efficacy of adding UFUR (UFT, tegafur/uracil) into weekly docetaxel treatment for non-small cell lung cancer (NSCLC) patients who failed previous platinum-based chemotherapy. Methods: Patients were randomized into two arms: docetaxel 40 mg/m2 intravenous infusion (IV) on days 1 and 8 of every 3 weeks (arm D), and docetaxel 35 mg/m2 IV on days 1 and 8 plus daily oral UFUR 150 mg/m2 of every 3 weeks (arm DU), with arm D as a control arm. Treatment was given to a maximum of 6 cycles and carried out in the outpatient clinic. Results: From January 2005 to March 2006, 48 patients were enrolled and randomized into the study, with 24 patients in each arm. The mean number of cycles of treatment was 4 in the D arm and 3.5 in the DU arm. Objective response rates were 29.2% in the D arm and 8.3% in the DU arm (p = 0.067). Toxicities were few and mild in degree in both arms. Median time to disease progression was 4.5 months in the D arm and 2.1 months in the DU arm (p = 0.4682). Median survival time was 10.9 months in the D arm and 15.2 months in the DU arm (p = 0.8442). Conclusions: The addition of UFUR to weekly docetaxel treatment did not improve response rate and time to disease progression in NSCLC patients who failed previous platinum-based chemotherapy.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalLung Cancer
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

Keywords

  • Docetaxel
  • Non-small cell lung cancer
  • Salvage therapy
  • UFUR

ASJC Scopus subject areas

  • Oncology

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