Pharmacotherapy for Obesity: Past, Present and Future

Ya Wen Hsu, Da Chen Chu, Po Wen Ku, Tsan Hon Liou, Pesus Chou

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The prevalence of obesity has rapidly increased in all industrialized countries in the past few decades, most likely due to dietary and lifestyle changes. Since 1980, the prevalence of obesity has increased threefold or more worldwide. Obesity is associated with a number of diseases and metabolic abnormalities, many of which have high morbidity and mortality rates. These diseases include type 2 diabetes, hypertension, dyslipidemia, coronary heart disease, gallbladder disease, and some cancers. Even relatively modest decreases in body-weight (5-10% of the initial body weight) lead to marked improvements in blood pressure, and sugar and lipid control in obese patients. Obesity treatment should begin with lifestyle changes that focus on behavioral modifications, diet control, and regular exercise. Pharmacotherapy provides an adjunct for obesity treatment, but should be used in conjunction with non-pharmacological approaches such as reduced caloric intake and increased exercise. The history of pharmacotherapy for obesity is no great success story because most anti-obesity drugs have been withdrawn from the market based on the US Food and Drug Administration warnings of serious adverse reactions. At present, only orlistat and sibutramine have been approved by the US Food and Drug Administration for long-term use, but sibutramine was withdrawn from sale in the European Union in January 2010. Rimonabant was approved for use in the European Union in 2006 but officially withdrawn in 2009. There are still many compounds under clinical development, including a new cannabinoid-1 receptor antagonist, a 5-HT2c receptor agonist, ghrelin receptor antagonists, and inhibitors of gastrointestinal lipases. All of these compounds are still in preclinical or early clinical development stages. It will take time to tell whether these compounds can be used as anti-obesity drugs in the near future.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume2
Issue number3
DOIs
Publication statusPublished - Jun 2010

Fingerprint

sibutramine
Obesity
Drug Therapy
Anti-Obesity Agents
rimonabant
European Union
United States Food and Drug Administration
Life Style
Ghrelin Receptor
Cannabinoid Receptor Antagonists
Exercise
Gallbladder Diseases
Diet Therapy
Metabolic Diseases
Dyslipidemias
Energy Intake
Lipase
Developed Countries
Type 2 Diabetes Mellitus
Coronary Disease

Keywords

  • Orlistat
  • Overweight
  • Rimonabant
  • Sibutramine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pharmacotherapy for Obesity : Past, Present and Future. / Hsu, Ya Wen; Chu, Da Chen; Ku, Po Wen; Liou, Tsan Hon; Chou, Pesus.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 2, No. 3, 06.2010, p. 118-123.

Research output: Contribution to journalArticle

Hsu, Ya Wen ; Chu, Da Chen ; Ku, Po Wen ; Liou, Tsan Hon ; Chou, Pesus. / Pharmacotherapy for Obesity : Past, Present and Future. In: Journal of Experimental and Clinical Medicine(Taiwan). 2010 ; Vol. 2, No. 3. pp. 118-123.
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