Abstract
The pharmacological effects of synthetic butylidenephthalide (Bdph), the most potent antispasmodic agent found in the neutral oil of Ligusticum wallichii Franch., were examined in this study. In vivo, Bdph exerted a significant antihypertensive effect in anaesthetized renal hypertensive rats at a dose of 30 mg/kg (i.v. or i.p.), or 60 mg/kg (p.o.). Bdph antagonized noradrenaline (NA) induced increases in blood pressure in anaesthetized normotensive rats. In addition, Bdph prevented the pituitrin-induced T-wave lowering of the ECG in anaesthetized rats. It also dose-dependently decreased coronary arterial pressure in dogs. It is concluded that Bdph dilates coronary vessels. In vitro, Bdph non-competitively antagonized adrenaline-induced contraction in isolated rabbit aortic strips. It also significantly antagonized the NA-induced maximum decrease in perfusion rate of isolated rabbit ears. However, the vasodilator effect may cause a heat loss because Bdph significantly lowered the rectal temperature of rats at ambient temperature of 20°C, but not at 30°C. Bdph might be a useful coronary dilator and antihypertensive drug.
| Original language | English |
|---|---|
| Pages (from-to) | 321-326 |
| Number of pages | 6 |
| Journal | Phytotherapy Research |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1994 |
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Keywords
- antihypertensive
- antispasmodic
- butylidenephthalide
- coronary dilator
- Ligusticum wallichii Franch.
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Pharmacological effects of butylidenephthalide. / Ko, W. C.; Chang, L. D.; Wang, G. Y.; Lin, L. C.
In: Phytotherapy Research, Vol. 8, No. 6, 1994, p. 321-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacological effects of butylidenephthalide
AU - Ko, W. C.
AU - Chang, L. D.
AU - Wang, G. Y.
AU - Lin, L. C.
PY - 1994
Y1 - 1994
N2 - The pharmacological effects of synthetic butylidenephthalide (Bdph), the most potent antispasmodic agent found in the neutral oil of Ligusticum wallichii Franch., were examined in this study. In vivo, Bdph exerted a significant antihypertensive effect in anaesthetized renal hypertensive rats at a dose of 30 mg/kg (i.v. or i.p.), or 60 mg/kg (p.o.). Bdph antagonized noradrenaline (NA) induced increases in blood pressure in anaesthetized normotensive rats. In addition, Bdph prevented the pituitrin-induced T-wave lowering of the ECG in anaesthetized rats. It also dose-dependently decreased coronary arterial pressure in dogs. It is concluded that Bdph dilates coronary vessels. In vitro, Bdph non-competitively antagonized adrenaline-induced contraction in isolated rabbit aortic strips. It also significantly antagonized the NA-induced maximum decrease in perfusion rate of isolated rabbit ears. However, the vasodilator effect may cause a heat loss because Bdph significantly lowered the rectal temperature of rats at ambient temperature of 20°C, but not at 30°C. Bdph might be a useful coronary dilator and antihypertensive drug.
AB - The pharmacological effects of synthetic butylidenephthalide (Bdph), the most potent antispasmodic agent found in the neutral oil of Ligusticum wallichii Franch., were examined in this study. In vivo, Bdph exerted a significant antihypertensive effect in anaesthetized renal hypertensive rats at a dose of 30 mg/kg (i.v. or i.p.), or 60 mg/kg (p.o.). Bdph antagonized noradrenaline (NA) induced increases in blood pressure in anaesthetized normotensive rats. In addition, Bdph prevented the pituitrin-induced T-wave lowering of the ECG in anaesthetized rats. It also dose-dependently decreased coronary arterial pressure in dogs. It is concluded that Bdph dilates coronary vessels. In vitro, Bdph non-competitively antagonized adrenaline-induced contraction in isolated rabbit aortic strips. It also significantly antagonized the NA-induced maximum decrease in perfusion rate of isolated rabbit ears. However, the vasodilator effect may cause a heat loss because Bdph significantly lowered the rectal temperature of rats at ambient temperature of 20°C, but not at 30°C. Bdph might be a useful coronary dilator and antihypertensive drug.
KW - antihypertensive
KW - antispasmodic
KW - butylidenephthalide
KW - coronary dilator
KW - Ligusticum wallichii Franch.
UR - http://www.scopus.com/inward/record.url?scp=0028096655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028096655&partnerID=8YFLogxK
U2 - 10.1002/ptr.2650080602
DO - 10.1002/ptr.2650080602
M3 - Article
VL - 8
SP - 321
EP - 326
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 6
ER -